3P2X
Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Insulin | polymer | 21 | 2383.7 | 2 | UniProt (P01308) | homo sapiens | Insulin A chain |
| 2 | B, D (B, D) | Insulin | polymer | 30 | 3448.0 | 2 | UniProt (P01308) Pfam (PF00049) | homo sapiens | Insulin B chain |
| 3 | E, H (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, I (B, D) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | G (C) | PHENOL | non-polymer | 94.1 | 1 | Chemie (IPH) | |||
| 6 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
B, D: 1 - 30 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| Dal 8 | Gly 32 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 11663.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 295.8 | |
| All* | Total formula weight | 11959.2 |
