3P33

Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity

Summary for 3P33
Related1XDA 3P2X
DescriptorInsulin, PHENOL, ZINC ION, ... (6 entities in total)
Functional Keywordszinc-binding site, long-acting insulin analog, receptor binding protein engineering, global health, insulin fibrillation, hormone
Biological sourceHomo Sapiens (human)
More
Cellular locationSecreted: P01308 P01308
Total number of polymer chains8
Total formula weight24050.50
Authors
Hua, Q.X.,Wan, Z.L.,Huang, K.,Hu, S.Q.,Phillip, N.F.,Jia, W.H.,Whittingham, J.,Dodson, G.G.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2010-10-04, release date: 2011-11-23, Last modification date: 2014-10-15)
Primary citationDodson, G.G.,Hu, S.Q.,Hua, Q.X.,Huang, K.,Jia, W.H.,Katsoyannis, P.G.,Phillip, N.F.,Wan, Z.L.,Weiss, M.A.,Whittingham, J.
Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published,
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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PDB entries from 2021-06-23