3P33
Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G | Insulin | polymer | 21 | 2383.7 | 4 | UniProt (P01308) In PDB | Homo Sapiens | Insulin A chain |
| 2 | B, D, F, H | Insulin | polymer | 30 | 3434.0 | 4 | UniProt (P01308) Pfam (PF00049) In PDB | Homo Sapiens | Insulin B chain |
| 3 | A, C, E, G | PHENOL | non-polymer | 94.1 | 4 | Chemie (IPH) | |||
| 4 | B, D, F, H | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | B, D, F, H | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 6 | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 23270.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 779.9 | |
| All* | Total formula weight | 24050.5 |
