3P33

Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
A, C, E, GInsulinpolymer212383.74
UniProt (P01308)
Homo Sapiens@PDBjInsulin A chain
B, D, F, HInsulinpolymer303434.04
UniProt (P01308)
Homo Sapiens@PDBjInsulin B chain
A, C, E, GPHENOLnon-polymer94.14
Chemie (IPH)
B, D, F, HZINC IONnon-polymer65.44
Chemie (ZN)
B, D, F, HCHLORIDE IONnon-polymer35.54
Chemie (CL)
waterwater18.090
Chemie (HOH)

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains8
Total molecular weight23270.6
Non-Polymers*Number of molecules12
Total molecular weight779.9
All*Total molecular weight24050.5
*Water molecules are not included.
167327
PDB entries from 2020-08-05