3P33

Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005788cellular_componentendoplasmic reticulum lumen
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0031904cellular_componentendosome lumen
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005796cellular_componentGolgi lumen
A0000139cellular_componentGolgi membrane
A0034774cellular_componentsecretory granule lumen
A0030133cellular_componenttransport vesicle
A0005179molecular_functionhormone activity
A0042802molecular_functionidentical protein binding
A0005158molecular_functioninsulin receptor binding
A0005159molecular_functioninsulin-like growth factor receptor binding
A0002020molecular_functionprotease binding
A0032148biological_processactivation of protein kinase B activity
A0006953biological_processacute-phase response
A0046631biological_processalpha-beta T cell activation
A0007267biological_processcell-cell signaling
A0044267biological_processcellular protein metabolic process
A0050890biological_processcognition
A0006888biological_processER to Golgi vesicle-mediated transport
A0055089biological_processfatty acid homeostasis
A0007186biological_processG protein-coupled receptor signaling pathway
A0042593biological_processglucose homeostasis
A0006006biological_processglucose metabolic process
A0008286biological_processinsulin receptor signaling pathway
A0002674biological_processnegative regulation of acute inflammatory response
A0097756biological_processnegative regulation of blood vessel diameter
A0045922biological_processnegative regulation of fatty acid metabolic process
A2000252biological_processnegative regulation of feeding behavior
A0045721biological_processnegative regulation of gluconeogenesis
A0045818biological_processnegative regulation of glycogen catabolic process
A0050995biological_processnegative regulation of lipid catabolic process
A0033861biological_processnegative regulation of NAD(P)H oxidase activity
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A0042177biological_processnegative regulation of protein catabolic process
A0032460biological_processnegative regulation of protein oligomerization
A0050709biological_processnegative regulation of protein secretion
A0045861biological_processnegative regulation of proteolysis
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A0060266biological_processnegative regulation of respiratory burst involved in inflammatory response
A1990535biological_processneuron projection maintenance
A0097755biological_processpositive regulation of blood vessel diameter
A0090336biological_processpositive regulation of brown fat cell differentiation
A0045597biological_processpositive regulation of cell differentiation
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0008284biological_processpositive regulation of cell proliferation
A0032270biological_processpositive regulation of cellular protein metabolic process
A0050715biological_processpositive regulation of cytokine secretion
A1902952biological_processpositive regulation of dendritic spine maintenance
A0010628biological_processpositive regulation of gene expression
A0046326biological_processpositive regulation of glucose import
A0045725biological_processpositive regulation of glycogen biosynthetic process
A0045821biological_processpositive regulation of glycolytic process
A0046628biological_processpositive regulation of insulin receptor signaling pathway
A0046889biological_processpositive regulation of lipid biosynthetic process
A1900273biological_processpositive regulation of long-term synaptic potentiation
A0043410biological_processpositive regulation of MAPK cascade
A0045840biological_processpositive regulation of mitotic nuclear division
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0010750biological_processpositive regulation of nitric oxide mediated signal transduction
A0051000biological_processpositive regulation of nitric-oxide synthase activity
A0090277biological_processpositive regulation of peptide hormone secretion
A0014068biological_processpositive regulation of phosphatidylinositol 3-kinase signaling
A0031954biological_processpositive regulation of protein autophosphorylation
A0051897biological_processpositive regulation of protein kinase B signaling
A1900182biological_processpositive regulation of protein localization to nucleus
A0060267biological_processpositive regulation of respiratory burst
A0006521biological_processregulation of cellular amino acid metabolic process
A0032880biological_processregulation of protein localization
A1903076biological_processregulation of protein localization to plasma membrane
A0050708biological_processregulation of protein secretion
A0048167biological_processregulation of synaptic plasticity
A0006355biological_processregulation of transcription, DNA-templated
A0022898biological_processregulation of transmembrane transporter activity
A0042060biological_processwound healing
C0005788cellular_componentendoplasmic reticulum lumen
C0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
C0031904cellular_componentendosome lumen
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005796cellular_componentGolgi lumen
C0000139cellular_componentGolgi membrane
C0034774cellular_componentsecretory granule lumen
C0030133cellular_componenttransport vesicle
C0005179molecular_functionhormone activity
C0042802molecular_functionidentical protein binding
C0005158molecular_functioninsulin receptor binding
C0005159molecular_functioninsulin-like growth factor receptor binding
C0002020molecular_functionprotease binding
C0032148biological_processactivation of protein kinase B activity
C0006953biological_processacute-phase response
C0046631biological_processalpha-beta T cell activation
C0007267biological_processcell-cell signaling
C0044267biological_processcellular protein metabolic process
C0050890biological_processcognition
C0006888biological_processER to Golgi vesicle-mediated transport
C0055089biological_processfatty acid homeostasis
C0007186biological_processG protein-coupled receptor signaling pathway
C0042593biological_processglucose homeostasis
C0006006biological_processglucose metabolic process
C0008286biological_processinsulin receptor signaling pathway
C0002674biological_processnegative regulation of acute inflammatory response
C0097756biological_processnegative regulation of blood vessel diameter
C0045922biological_processnegative regulation of fatty acid metabolic process
C2000252biological_processnegative regulation of feeding behavior
C0045721biological_processnegative regulation of gluconeogenesis
C0045818biological_processnegative regulation of glycogen catabolic process
C0050995biological_processnegative regulation of lipid catabolic process
C0033861biological_processnegative regulation of NAD(P)H oxidase activity
C1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C0042177biological_processnegative regulation of protein catabolic process
C0032460biological_processnegative regulation of protein oligomerization
C0050709biological_processnegative regulation of protein secretion
C0045861biological_processnegative regulation of proteolysis
C1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
C0060266biological_processnegative regulation of respiratory burst involved in inflammatory response
C1990535biological_processneuron projection maintenance
C0097755biological_processpositive regulation of blood vessel diameter
C0090336biological_processpositive regulation of brown fat cell differentiation
C0045597biological_processpositive regulation of cell differentiation
C0030307biological_processpositive regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0008284biological_processpositive regulation of cell proliferation
C0032270biological_processpositive regulation of cellular protein metabolic process
C0050715biological_processpositive regulation of cytokine secretion
C1902952biological_processpositive regulation of dendritic spine maintenance
C0010628biological_processpositive regulation of gene expression
C0046326biological_processpositive regulation of glucose import
C0045725biological_processpositive regulation of glycogen biosynthetic process
C0045821biological_processpositive regulation of glycolytic process
C0046628biological_processpositive regulation of insulin receptor signaling pathway
C0046889biological_processpositive regulation of lipid biosynthetic process
C1900273biological_processpositive regulation of long-term synaptic potentiation
C0043410biological_processpositive regulation of MAPK cascade
C0045840biological_processpositive regulation of mitotic nuclear division
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0010750biological_processpositive regulation of nitric oxide mediated signal transduction
C0051000biological_processpositive regulation of nitric-oxide synthase activity
C0090277biological_processpositive regulation of peptide hormone secretion
C0014068biological_processpositive regulation of phosphatidylinositol 3-kinase signaling
C0031954biological_processpositive regulation of protein autophosphorylation
C0051897biological_processpositive regulation of protein kinase B signaling
C1900182biological_processpositive regulation of protein localization to nucleus
C0060267biological_processpositive regulation of respiratory burst
C0006521biological_processregulation of cellular amino acid metabolic process
C0032880biological_processregulation of protein localization
C1903076biological_processregulation of protein localization to plasma membrane
C0050708biological_processregulation of protein secretion
C0048167biological_processregulation of synaptic plasticity
C0006355biological_processregulation of transcription, DNA-templated
C0022898biological_processregulation of transmembrane transporter activity
C0042060biological_processwound healing
E0005788cellular_componentendoplasmic reticulum lumen
E0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
E0031904cellular_componentendosome lumen
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005796cellular_componentGolgi lumen
E0000139cellular_componentGolgi membrane
E0034774cellular_componentsecretory granule lumen
E0030133cellular_componenttransport vesicle
E0005179molecular_functionhormone activity
E0042802molecular_functionidentical protein binding
E0005158molecular_functioninsulin receptor binding
E0005159molecular_functioninsulin-like growth factor receptor binding
E0002020molecular_functionprotease binding
E0032148biological_processactivation of protein kinase B activity
E0006953biological_processacute-phase response
E0046631biological_processalpha-beta T cell activation
E0007267biological_processcell-cell signaling
E0044267biological_processcellular protein metabolic process
E0050890biological_processcognition
E0006888biological_processER to Golgi vesicle-mediated transport
E0055089biological_processfatty acid homeostasis
E0007186biological_processG protein-coupled receptor signaling pathway
E0042593biological_processglucose homeostasis
E0006006biological_processglucose metabolic process
E0008286biological_processinsulin receptor signaling pathway
E0002674biological_processnegative regulation of acute inflammatory response
E0097756biological_processnegative regulation of blood vessel diameter
E0045922biological_processnegative regulation of fatty acid metabolic process
E2000252biological_processnegative regulation of feeding behavior
E0045721biological_processnegative regulation of gluconeogenesis
E0045818biological_processnegative regulation of glycogen catabolic process
E0050995biological_processnegative regulation of lipid catabolic process
E0033861biological_processnegative regulation of NAD(P)H oxidase activity
E1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E0042177biological_processnegative regulation of protein catabolic process
E0032460biological_processnegative regulation of protein oligomerization
E0050709biological_processnegative regulation of protein secretion
E0045861biological_processnegative regulation of proteolysis
E1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
E0060266biological_processnegative regulation of respiratory burst involved in inflammatory response
E1990535biological_processneuron projection maintenance
E0097755biological_processpositive regulation of blood vessel diameter
E0090336biological_processpositive regulation of brown fat cell differentiation
E0045597biological_processpositive regulation of cell differentiation
E0030307biological_processpositive regulation of cell growth
E0030335biological_processpositive regulation of cell migration
E0008284biological_processpositive regulation of cell proliferation
E0032270biological_processpositive regulation of cellular protein metabolic process
E0050715biological_processpositive regulation of cytokine secretion
E1902952biological_processpositive regulation of dendritic spine maintenance
E0010628biological_processpositive regulation of gene expression
E0046326biological_processpositive regulation of glucose import
E0045725biological_processpositive regulation of glycogen biosynthetic process
E0045821biological_processpositive regulation of glycolytic process
E0046628biological_processpositive regulation of insulin receptor signaling pathway
E0046889biological_processpositive regulation of lipid biosynthetic process
E1900273biological_processpositive regulation of long-term synaptic potentiation
E0043410biological_processpositive regulation of MAPK cascade
E0045840biological_processpositive regulation of mitotic nuclear division
E0051092biological_processpositive regulation of NF-kappaB transcription factor activity
E0010750biological_processpositive regulation of nitric oxide mediated signal transduction
E0051000biological_processpositive regulation of nitric-oxide synthase activity
E0090277biological_processpositive regulation of peptide hormone secretion
E0014068biological_processpositive regulation of phosphatidylinositol 3-kinase signaling
E0031954biological_processpositive regulation of protein autophosphorylation
E0051897biological_processpositive regulation of protein kinase B signaling
E1900182biological_processpositive regulation of protein localization to nucleus
E0060267biological_processpositive regulation of respiratory burst
E0006521biological_processregulation of cellular amino acid metabolic process
E0032880biological_processregulation of protein localization
E1903076biological_processregulation of protein localization to plasma membrane
E0050708biological_processregulation of protein secretion
E0048167biological_processregulation of synaptic plasticity
E0006355biological_processregulation of transcription, DNA-templated
E0022898biological_processregulation of transmembrane transporter activity
E0042060biological_processwound healing
G0005788cellular_componentendoplasmic reticulum lumen
G0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
G0031904cellular_componentendosome lumen
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005796cellular_componentGolgi lumen
G0000139cellular_componentGolgi membrane
G0034774cellular_componentsecretory granule lumen
G0030133cellular_componenttransport vesicle
G0005179molecular_functionhormone activity
G0042802molecular_functionidentical protein binding
G0005158molecular_functioninsulin receptor binding
G0005159molecular_functioninsulin-like growth factor receptor binding
G0002020molecular_functionprotease binding
G0032148biological_processactivation of protein kinase B activity
G0006953biological_processacute-phase response
G0046631biological_processalpha-beta T cell activation
G0007267biological_processcell-cell signaling
G0044267biological_processcellular protein metabolic process
G0050890biological_processcognition
G0006888biological_processER to Golgi vesicle-mediated transport
G0055089biological_processfatty acid homeostasis
G0007186biological_processG protein-coupled receptor signaling pathway
G0042593biological_processglucose homeostasis
G0006006biological_processglucose metabolic process
G0008286biological_processinsulin receptor signaling pathway
G0002674biological_processnegative regulation of acute inflammatory response
G0097756biological_processnegative regulation of blood vessel diameter
G0045922biological_processnegative regulation of fatty acid metabolic process
G2000252biological_processnegative regulation of feeding behavior
G0045721biological_processnegative regulation of gluconeogenesis
G0045818biological_processnegative regulation of glycogen catabolic process
G0050995biological_processnegative regulation of lipid catabolic process
G0033861biological_processnegative regulation of NAD(P)H oxidase activity
G1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G0042177biological_processnegative regulation of protein catabolic process
G0032460biological_processnegative regulation of protein oligomerization
G0050709biological_processnegative regulation of protein secretion
G0045861biological_processnegative regulation of proteolysis
G1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
G0060266biological_processnegative regulation of respiratory burst involved in inflammatory response
G1990535biological_processneuron projection maintenance
G0097755biological_processpositive regulation of blood vessel diameter
G0090336biological_processpositive regulation of brown fat cell differentiation
G0045597biological_processpositive regulation of cell differentiation
G0030307biological_processpositive regulation of cell growth
G0030335biological_processpositive regulation of cell migration
G0008284biological_processpositive regulation of cell proliferation
G0032270biological_processpositive regulation of cellular protein metabolic process
G0050715biological_processpositive regulation of cytokine secretion
G1902952biological_processpositive regulation of dendritic spine maintenance
G0010628biological_processpositive regulation of gene expression
G0046326biological_processpositive regulation of glucose import
G0045725biological_processpositive regulation of glycogen biosynthetic process
G0045821biological_processpositive regulation of glycolytic process
G0046628biological_processpositive regulation of insulin receptor signaling pathway
G0046889biological_processpositive regulation of lipid biosynthetic process
G1900273biological_processpositive regulation of long-term synaptic potentiation
G0043410biological_processpositive regulation of MAPK cascade
G0045840biological_processpositive regulation of mitotic nuclear division
G0051092biological_processpositive regulation of NF-kappaB transcription factor activity
G0010750biological_processpositive regulation of nitric oxide mediated signal transduction
G0051000biological_processpositive regulation of nitric-oxide synthase activity
G0090277biological_processpositive regulation of peptide hormone secretion
G0014068biological_processpositive regulation of phosphatidylinositol 3-kinase signaling
G0031954biological_processpositive regulation of protein autophosphorylation
G0051897biological_processpositive regulation of protein kinase B signaling
G1900182biological_processpositive regulation of protein localization to nucleus
G0060267biological_processpositive regulation of respiratory burst
G0006521biological_processregulation of cellular amino acid metabolic process
G0032880biological_processregulation of protein localization
G1903076biological_processregulation of protein localization to plasma membrane
G0050708biological_processregulation of protein secretion
G0048167biological_processregulation of synaptic plasticity
G0006355biological_processregulation of transcription, DNA-templated
G0022898biological_processregulation of transmembrane transporter activity
G0042060biological_processwound healing
B0005788cellular_componentendoplasmic reticulum lumen
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0031904cellular_componentendosome lumen
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005796cellular_componentGolgi lumen
B0000139cellular_componentGolgi membrane
B0034774cellular_componentsecretory granule lumen
B0030133cellular_componenttransport vesicle
B0005179molecular_functionhormone activity
B0042802molecular_functionidentical protein binding
B0005158molecular_functioninsulin receptor binding
B0005159molecular_functioninsulin-like growth factor receptor binding
B0002020molecular_functionprotease binding
B0032148biological_processactivation of protein kinase B activity
B0006953biological_processacute-phase response
B0046631biological_processalpha-beta T cell activation
B0007267biological_processcell-cell signaling
B0044267biological_processcellular protein metabolic process
B0050890biological_processcognition
B0006888biological_processER to Golgi vesicle-mediated transport
B0055089biological_processfatty acid homeostasis
B0007186biological_processG protein-coupled receptor signaling pathway
B0042593biological_processglucose homeostasis
B0006006biological_processglucose metabolic process
B0008286biological_processinsulin receptor signaling pathway
B0002674biological_processnegative regulation of acute inflammatory response
B0097756biological_processnegative regulation of blood vessel diameter
B0045922biological_processnegative regulation of fatty acid metabolic process
B2000252biological_processnegative regulation of feeding behavior
B0045721biological_processnegative regulation of gluconeogenesis
B0045818biological_processnegative regulation of glycogen catabolic process
B0050995biological_processnegative regulation of lipid catabolic process
B0033861biological_processnegative regulation of NAD(P)H oxidase activity
B1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B0042177biological_processnegative regulation of protein catabolic process
B0032460biological_processnegative regulation of protein oligomerization
B0050709biological_processnegative regulation of protein secretion
B0045861biological_processnegative regulation of proteolysis
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B0060266biological_processnegative regulation of respiratory burst involved in inflammatory response
B1990535biological_processneuron projection maintenance
B0097755biological_processpositive regulation of blood vessel diameter
B0090336biological_processpositive regulation of brown fat cell differentiation
B0045597biological_processpositive regulation of cell differentiation
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0008284biological_processpositive regulation of cell proliferation
B0032270biological_processpositive regulation of cellular protein metabolic process
B0050715biological_processpositive regulation of cytokine secretion
B1902952biological_processpositive regulation of dendritic spine maintenance
B0010628biological_processpositive regulation of gene expression
B0046326biological_processpositive regulation of glucose import
B0045725biological_processpositive regulation of glycogen biosynthetic process
B0045821biological_processpositive regulation of glycolytic process
B0046628biological_processpositive regulation of insulin receptor signaling pathway
B0046889biological_processpositive regulation of lipid biosynthetic process
B1900273biological_processpositive regulation of long-term synaptic potentiation
B0043410biological_processpositive regulation of MAPK cascade
B0045840biological_processpositive regulation of mitotic nuclear division
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0010750biological_processpositive regulation of nitric oxide mediated signal transduction
B0051000biological_processpositive regulation of nitric-oxide synthase activity
B0090277biological_processpositive regulation of peptide hormone secretion
B0014068biological_processpositive regulation of phosphatidylinositol 3-kinase signaling
B0031954biological_processpositive regulation of protein autophosphorylation
B0051897biological_processpositive regulation of protein kinase B signaling
B1900182biological_processpositive regulation of protein localization to nucleus
B0060267biological_processpositive regulation of respiratory burst
B0006521biological_processregulation of cellular amino acid metabolic process
B0032880biological_processregulation of protein localization
B1903076biological_processregulation of protein localization to plasma membrane
B0050708biological_processregulation of protein secretion
B0048167biological_processregulation of synaptic plasticity
B0006355biological_processregulation of transcription, DNA-templated
B0022898biological_processregulation of transmembrane transporter activity
B0042060biological_processwound healing
D0005788cellular_componentendoplasmic reticulum lumen
D0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
D0031904cellular_componentendosome lumen
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005796cellular_componentGolgi lumen
D0000139cellular_componentGolgi membrane
D0034774cellular_componentsecretory granule lumen
D0030133cellular_componenttransport vesicle
D0005179molecular_functionhormone activity
D0042802molecular_functionidentical protein binding
D0005158molecular_functioninsulin receptor binding
D0005159molecular_functioninsulin-like growth factor receptor binding
D0002020molecular_functionprotease binding
D0032148biological_processactivation of protein kinase B activity
D0006953biological_processacute-phase response
D0046631biological_processalpha-beta T cell activation
D0007267biological_processcell-cell signaling
D0044267biological_processcellular protein metabolic process
D0050890biological_processcognition
D0006888biological_processER to Golgi vesicle-mediated transport
D0055089biological_processfatty acid homeostasis
D0007186biological_processG protein-coupled receptor signaling pathway
D0042593biological_processglucose homeostasis
D0006006biological_processglucose metabolic process
D0008286biological_processinsulin receptor signaling pathway
D0002674biological_processnegative regulation of acute inflammatory response
D0097756biological_processnegative regulation of blood vessel diameter
D0045922biological_processnegative regulation of fatty acid metabolic process
D2000252biological_processnegative regulation of feeding behavior
D0045721biological_processnegative regulation of gluconeogenesis
D0045818biological_processnegative regulation of glycogen catabolic process
D0050995biological_processnegative regulation of lipid catabolic process
D0033861biological_processnegative regulation of NAD(P)H oxidase activity
D1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D0042177biological_processnegative regulation of protein catabolic process
D0032460biological_processnegative regulation of protein oligomerization
D0050709biological_processnegative regulation of protein secretion
D0045861biological_processnegative regulation of proteolysis
D1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
D0060266biological_processnegative regulation of respiratory burst involved in inflammatory response
D1990535biological_processneuron projection maintenance
D0097755biological_processpositive regulation of blood vessel diameter
D0090336biological_processpositive regulation of brown fat cell differentiation
D0045597biological_processpositive regulation of cell differentiation
D0030307biological_processpositive regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0008284biological_processpositive regulation of cell proliferation
D0032270biological_processpositive regulation of cellular protein metabolic process
D0050715biological_processpositive regulation of cytokine secretion
D1902952biological_processpositive regulation of dendritic spine maintenance
D0010628biological_processpositive regulation of gene expression
D0046326biological_processpositive regulation of glucose import
D0045725biological_processpositive regulation of glycogen biosynthetic process
D0045821biological_processpositive regulation of glycolytic process
D0046628biological_processpositive regulation of insulin receptor signaling pathway
D0046889biological_processpositive regulation of lipid biosynthetic process
D1900273biological_processpositive regulation of long-term synaptic potentiation
D0043410biological_processpositive regulation of MAPK cascade
D0045840biological_processpositive regulation of mitotic nuclear division
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0010750biological_processpositive regulation of nitric oxide mediated signal transduction
D0051000biological_processpositive regulation of nitric-oxide synthase activity
D0090277biological_processpositive regulation of peptide hormone secretion
D0014068biological_processpositive regulation of phosphatidylinositol 3-kinase signaling
D0031954biological_processpositive regulation of protein autophosphorylation
D0051897biological_processpositive regulation of protein kinase B signaling
D1900182biological_processpositive regulation of protein localization to nucleus
D0060267biological_processpositive regulation of respiratory burst
D0006521biological_processregulation of cellular amino acid metabolic process
D0032880biological_processregulation of protein localization
D1903076biological_processregulation of protein localization to plasma membrane
D0050708biological_processregulation of protein secretion
D0048167biological_processregulation of synaptic plasticity
D0006355biological_processregulation of transcription, DNA-templated
D0022898biological_processregulation of transmembrane transporter activity
D0042060biological_processwound healing
F0005788cellular_componentendoplasmic reticulum lumen
F0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
F0031904cellular_componentendosome lumen
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005796cellular_componentGolgi lumen
F0000139cellular_componentGolgi membrane
F0034774cellular_componentsecretory granule lumen
F0030133cellular_componenttransport vesicle
F0005179molecular_functionhormone activity
F0042802molecular_functionidentical protein binding
F0005158molecular_functioninsulin receptor binding
F0005159molecular_functioninsulin-like growth factor receptor binding
F0002020molecular_functionprotease binding
F0032148biological_processactivation of protein kinase B activity
F0006953biological_processacute-phase response
F0046631biological_processalpha-beta T cell activation
F0007267biological_processcell-cell signaling
F0044267biological_processcellular protein metabolic process
F0050890biological_processcognition
F0006888biological_processER to Golgi vesicle-mediated transport
F0055089biological_processfatty acid homeostasis
F0007186biological_processG protein-coupled receptor signaling pathway
F0042593biological_processglucose homeostasis
F0006006biological_processglucose metabolic process
F0008286biological_processinsulin receptor signaling pathway
F0002674biological_processnegative regulation of acute inflammatory response
F0097756biological_processnegative regulation of blood vessel diameter
F0045922biological_processnegative regulation of fatty acid metabolic process
F2000252biological_processnegative regulation of feeding behavior
F0045721biological_processnegative regulation of gluconeogenesis
F0045818biological_processnegative regulation of glycogen catabolic process
F0050995biological_processnegative regulation of lipid catabolic process
F0033861biological_processnegative regulation of NAD(P)H oxidase activity
F1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F0042177biological_processnegative regulation of protein catabolic process
F0032460biological_processnegative regulation of protein oligomerization
F0050709biological_processnegative regulation of protein secretion
F0045861biological_processnegative regulation of proteolysis
F1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
F0060266biological_processnegative regulation of respiratory burst involved in inflammatory response
F1990535biological_processneuron projection maintenance
F0097755biological_processpositive regulation of blood vessel diameter
F0090336biological_processpositive regulation of brown fat cell differentiation
F0045597biological_processpositive regulation of cell differentiation
F0030307biological_processpositive regulation of cell growth
F0030335biological_processpositive regulation of cell migration
F0008284biological_processpositive regulation of cell proliferation
F0032270biological_processpositive regulation of cellular protein metabolic process
F0050715biological_processpositive regulation of cytokine secretion
F1902952biological_processpositive regulation of dendritic spine maintenance
F0010628biological_processpositive regulation of gene expression
F0046326biological_processpositive regulation of glucose import
F0045725biological_processpositive regulation of glycogen biosynthetic process
F0045821biological_processpositive regulation of glycolytic process
F0046628biological_processpositive regulation of insulin receptor signaling pathway
F0046889biological_processpositive regulation of lipid biosynthetic process
F1900273biological_processpositive regulation of long-term synaptic potentiation
F0043410biological_processpositive regulation of MAPK cascade
F0045840biological_processpositive regulation of mitotic nuclear division
F0051092biological_processpositive regulation of NF-kappaB transcription factor activity
F0010750biological_processpositive regulation of nitric oxide mediated signal transduction
F0051000biological_processpositive regulation of nitric-oxide synthase activity
F0090277biological_processpositive regulation of peptide hormone secretion
F0014068biological_processpositive regulation of phosphatidylinositol 3-kinase signaling
F0031954biological_processpositive regulation of protein autophosphorylation
F0051897biological_processpositive regulation of protein kinase B signaling
F1900182biological_processpositive regulation of protein localization to nucleus
F0060267biological_processpositive regulation of respiratory burst
F0006521biological_processregulation of cellular amino acid metabolic process
F0032880biological_processregulation of protein localization
F1903076biological_processregulation of protein localization to plasma membrane
F0050708biological_processregulation of protein secretion
F0048167biological_processregulation of synaptic plasticity
F0006355biological_processregulation of transcription, DNA-templated
F0022898biological_processregulation of transmembrane transporter activity
F0042060biological_processwound healing
H0005788cellular_componentendoplasmic reticulum lumen
H0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
H0031904cellular_componentendosome lumen
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005796cellular_componentGolgi lumen
H0000139cellular_componentGolgi membrane
H0034774cellular_componentsecretory granule lumen
H0030133cellular_componenttransport vesicle
H0005179molecular_functionhormone activity
H0042802molecular_functionidentical protein binding
H0005158molecular_functioninsulin receptor binding
H0005159molecular_functioninsulin-like growth factor receptor binding
H0002020molecular_functionprotease binding
H0032148biological_processactivation of protein kinase B activity
H0006953biological_processacute-phase response
H0046631biological_processalpha-beta T cell activation
H0007267biological_processcell-cell signaling
H0044267biological_processcellular protein metabolic process
H0050890biological_processcognition
H0006888biological_processER to Golgi vesicle-mediated transport
H0055089biological_processfatty acid homeostasis
H0007186biological_processG protein-coupled receptor signaling pathway
H0042593biological_processglucose homeostasis
H0006006biological_processglucose metabolic process
H0008286biological_processinsulin receptor signaling pathway
H0002674biological_processnegative regulation of acute inflammatory response
H0097756biological_processnegative regulation of blood vessel diameter
H0045922biological_processnegative regulation of fatty acid metabolic process
H2000252biological_processnegative regulation of feeding behavior
H0045721biological_processnegative regulation of gluconeogenesis
H0045818biological_processnegative regulation of glycogen catabolic process
H0050995biological_processnegative regulation of lipid catabolic process
H0033861biological_processnegative regulation of NAD(P)H oxidase activity
H1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
H0042177biological_processnegative regulation of protein catabolic process
H0032460biological_processnegative regulation of protein oligomerization
H0050709biological_processnegative regulation of protein secretion
H0045861biological_processnegative regulation of proteolysis
H1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
H0060266biological_processnegative regulation of respiratory burst involved in inflammatory response
H1990535biological_processneuron projection maintenance
H0097755biological_processpositive regulation of blood vessel diameter
H0090336biological_processpositive regulation of brown fat cell differentiation
H0045597biological_processpositive regulation of cell differentiation
H0030307biological_processpositive regulation of cell growth
H0030335biological_processpositive regulation of cell migration
H0008284biological_processpositive regulation of cell proliferation
H0032270biological_processpositive regulation of cellular protein metabolic process
H0050715biological_processpositive regulation of cytokine secretion
H1902952biological_processpositive regulation of dendritic spine maintenance
H0010628biological_processpositive regulation of gene expression
H0046326biological_processpositive regulation of glucose import
H0045725biological_processpositive regulation of glycogen biosynthetic process
H0045821biological_processpositive regulation of glycolytic process
H0046628biological_processpositive regulation of insulin receptor signaling pathway
H0046889biological_processpositive regulation of lipid biosynthetic process
H1900273biological_processpositive regulation of long-term synaptic potentiation
H0043410biological_processpositive regulation of MAPK cascade
H0045840biological_processpositive regulation of mitotic nuclear division
H0051092biological_processpositive regulation of NF-kappaB transcription factor activity
H0010750biological_processpositive regulation of nitric oxide mediated signal transduction
H0051000biological_processpositive regulation of nitric-oxide synthase activity
H0090277biological_processpositive regulation of peptide hormone secretion
H0014068biological_processpositive regulation of phosphatidylinositol 3-kinase signaling
H0031954biological_processpositive regulation of protein autophosphorylation
H0051897biological_processpositive regulation of protein kinase B signaling
H1900182biological_processpositive regulation of protein localization to nucleus
H0060267biological_processpositive regulation of respiratory burst
H0006521biological_processregulation of cellular amino acid metabolic process
H0032880biological_processregulation of protein localization
H1903076biological_processregulation of protein localization to plasma membrane
H0050708biological_processregulation of protein secretion
H0048167biological_processregulation of synaptic plasticity
H0006355biological_processregulation of transcription, DNA-templated
H0022898biological_processregulation of transmembrane transporter activity
H0042060biological_processwound healing
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC16BINDING SITE FOR RESIDUE ZN B 31
ChainResidue
BHIS10
BHIS10
BHIS10
BCL32
BCL32
BCL32

AC26BINDING SITE FOR RESIDUE CL B 32
ChainResidue
BHIS10
BHIS10
BHIS10
BZN31
BZN31
BZN31

AC36BINDING SITE FOR RESIDUE ZN D 31
ChainResidue
DHIS10
DHIS10
DHIS10
DCL32
DCL32
DCL32

AC46BINDING SITE FOR RESIDUE CL D 32
ChainResidue
DHIS10
DHIS10
DHIS10
DZN31
DZN31
DZN31

AC56BINDING SITE FOR RESIDUE ZN F 31
ChainResidue
FHIS10
FHIS10
FHIS10
FCL32
FCL32
FCL32

AC66BINDING SITE FOR RESIDUE CL F 32
ChainResidue
FHIS10
FHIS10
FHIS10
FZN31
FZN31
FZN31

AC76BINDING SITE FOR RESIDUE ZN H 31
ChainResidue
HHIS10
HHIS10
HHIS10
HCL32
HCL32
HCL32

AC86BINDING SITE FOR RESIDUE CL H 32
ChainResidue
HHIS10
HHIS10
HHIS10
HZN31
HZN31
HZN31

AC95BINDING SITE FOR RESIDUE IPH A 100
ChainResidue
ACYS6
ASER9
AILE10
ACYS11
BLEU11

BC14BINDING SITE FOR RESIDUE IPH C 200
ChainResidue
CCYS6
CSER9
CCYS11
DHIS10

BC26BINDING SITE FOR RESIDUE IPH E 300
ChainResidue
ECYS6
ESER9
EILE10
ECYS11
FHIS5
FLEU11

BC37BINDING SITE FOR RESIDUE IPH G 400
ChainResidue
GCYS6
GSER9
GILE10
GCYS11
HHIS5
HHIS10
HLEU11

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
IPH_3p33_A_10010PHENOL binding site
ChainResidueligand
ACYS6-CYS7IPH: PHENOL
ASER9-CYS11IPH: PHENOL
ALEU16IPH: PHENOL
BCYS7IPH: PHENOL
BHIS10-LEU11IPH: PHENOL
BALA14IPH: PHENOL

IPH_3p33_C_20010PHENOL binding site
ChainResidueligand
CCYS6-CYS7IPH: PHENOL
CSER9-CYS11IPH: PHENOL
CLEU16IPH: PHENOL
DCYS7IPH: PHENOL
DHIS10-LEU11IPH: PHENOL
DALA14IPH: PHENOL

IPH_3p33_E_30010PHENOL binding site
ChainResidueligand
ECYS6-CYS7IPH: PHENOL
ESER9-CYS11IPH: PHENOL
ELEU16IPH: PHENOL
FCYS7IPH: PHENOL
FHIS10-LEU11IPH: PHENOL
FALA14IPH: PHENOL

IPH_3p33_G_40010PHENOL binding site
ChainResidueligand
GCYS6-CYS7IPH: PHENOL
GSER9-CYS11IPH: PHENOL
GLEU16IPH: PHENOL
HCYS7IPH: PHENOL
HHIS10-LEU11IPH: PHENOL
HALA14IPH: PHENOL

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails