3P33

Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity

Summary for 3P33

• Entry DOI: 10.2210/pdb3p33/pdb
• Related: 1XDA 3P2X
• Descriptor: Insulin, PHENOL, ZINC ION, ... (6 entities in total)
• Functional Keywords: zinc-binding site, long-acting insulin analog, receptor binding protein engineering, global health, insulin fibrillation, hormone
• Biological source: Homo Sapiens (human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 8
• Total formula weight: 24050.50

Authors

Hua, Q.X.,Wan, Z.L.,Huang, K.,Hu, S.Q.,Phillip, N.F.,Jia, W.H.,Whittingham, J.,Dodson, G.G.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2010-10-04, release date: 2011-11-23, Last modification date: 2023-09-06)

• Primary citation: Hua, Q.X.,Wan, Z.L.,Huang, K.,Hu, S.Q.,Phillip, N.F.,Jia, W.H.,Whittingham, J.,Dodson, G.G.,Katsoyannis, P.G.,Weiss, M.A.; Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)