3P33

Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity

Summary for 3P33

Related1XDA 3P2X
DescriptorInsulin, PHENOL, ZINC ION, ... (6 entities in total)
Functional Keywordszinc-binding site, long-acting insulin analog, receptor binding protein engineering, global health, insulin fibrillation, hormone
Biological sourceHomo Sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains8
Total molecular weight24050.5
Authors
Hua, Q.X.,Wan, Z.L.,Huang, K.,Hu, S.Q.,Phillip, N.F.,Jia, W.H.,Whittingham, J.,Dodson, G.G.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2010-10-04, release date: 2011-11-23, Last modification date: 2014-10-15)
Primary citation
Hua, Q.X.,Wan, Z.L.,Huang, K.,Hu, S.Q.,Phillip, N.F.,Jia, W.H.,Whittingham, J.,Dodson, G.G.,Katsoyannis, P.G.,Weiss, M.A.
Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published,
Experimental method
X-RAY DIFFRACTION (2.3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.299161.1%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3p33
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Molmil generated image of 3p33
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Molmil generated image of 3p33
rotated about y axis by 90°