3JSD

Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus

Summary for 3JSD
Related1TRZ
DescriptorInsulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total)
Functional Keywordsdiabetes mellitus, insulin's biosynthesis, proinsulin, insulin hexamer, carbohydrate metabolism, cleavage on pair of basic residues, disease mutation, disulfide bond, glucose metabolism, hormone, secreted
Cellular locationSecreted: P01308 P01308
Total number of polymer chains4
Total formula weight11959.19
Authors
Primary citationArvan, P.,Brange, J.,Dodson, E.J.,Dodson, G.G.,Hu, S.Q.,Hua, Q.X.,Huang, K.,Jia, W.H.,Katsoyannis, P.G.,Liu, M.,Nakagawa, S.H.,Turkenburg, M.,Wan, Z.L.,Wang, S.H.,Weiss, M.A.,Whittaker, J.,Whittingham, J.,Xu, B.
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published,
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation
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178938

PDB entries from 2021-06-16