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8JV7
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BU of 8jv7 by Molmil
Cryo-EM structure of the panda P2X7 receptor in complex with PPADS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(E)-[4-methanoyl-6-methyl-5-oxidanyl-3-(phosphonooxymethyl)pyridin-2-yl]diazenyl]benzene-1,3-disulfonic acid, P2X purinoceptor
Authors:Sheng, D, Hattori, M.
Deposit date:2023-06-27
Release date:2023-11-29
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists.
Elife, 12, 2024
8JV8
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Cryo-EM structure of the panda P2X7 receptor in complex with PPNDS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, P2X purinoceptor
Authors:Sheng, D, Hattori, M.
Deposit date:2023-06-27
Release date:2023-11-29
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists.
Elife, 12, 2024
4CPI
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streptavidin A86D mutant with love-hate ligand 4
Descriptor: 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N'-{2,6-bis[4-(morpholine-4- sulfonyl)phenyl]phenyl}pentanehydrazide, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Fairhead, M, Shen, D, Chan, L.K.M, Lowe, E.D, Donohoe, T.J, Howarth, M.
Deposit date:2014-02-06
Release date:2014-08-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction.
Bioorg.Med.Chem., 22, 2014
4CPH
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BU of 4cph by Molmil
trans-divalent streptavidin with love-hate ligand 4
Descriptor: 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N'-{2,6-bis[4-(morpholine-4- sulfonyl)phenyl]phenyl}pentanehydrazide, STREPTAVIDIN
Authors:Fairhead, M, Shen, D, Chan, L.K.M, Lowe, E.D, Donohoe, T.J, Howarth, M.
Deposit date:2014-02-06
Release date:2014-08-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction.
Bioorg.Med.Chem., 22, 2014
4CPF
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Wild-type streptavidin in complex with love-hate ligand 3 (LH3)
Descriptor: STREPTAVIDIN, methyl 4-(2-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H- thieno[3,4-d]imidazolidin-4-yl]pentanehydrazido}-3- [4-(methoxycarbonyl)phenyl]phenyl)benzoate
Authors:Fairhead, M, Shen, D, Chan, L.K.M, Lowe, E.D, Donohoe, T.J, Howarth, M.
Deposit date:2014-02-06
Release date:2014-08-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction.
Bioorg.Med.Chem., 22, 2014
4CPE
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Wild-type streptavidin in complex with love-hate ligand 1 (LH1)
Descriptor: (3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N-{2-[(2,6- diphenylphenyl)formamido]ethyl}pentanamide, STREPTAVIDIN
Authors:Fairhead, M, Shen, D, Chan, L.K.M, Lowe, E.D, Donohoe, T.J, Howarth, M.
Deposit date:2014-02-06
Release date:2014-08-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction.
Bioorg.Med.Chem., 22, 2014
7Y35
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Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
Descriptor: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z.
Deposit date:2022-06-09
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
To Be Published
7Y36
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BU of 7y36 by Molmil
Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ...
Authors:Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z.
Deposit date:2022-06-10
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
to be published
2N6F
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BU of 2n6f by Molmil
Structure of Pleiotrophin
Descriptor: Pleiotrophin
Authors:Ryan, E.O, Shen, D, Wang, X.
Deposit date:2015-08-20
Release date:2016-04-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural studies reveal an important role for the pleiotrophin C-terminus in mediating interactions with chondroitin sulfate.
Febs J., 283, 2016
4W60
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BU of 4w60 by Molmil
The structure of Vaccina virus H7 protein displays A Novel Phosphoinositide binding fold required for membrane biogenesis
Descriptor: Late protein H7
Authors:Kolli, S, Meng, X, Wu, X, Shengjuler, D, Cameron, C.E, Xiang, Y, Deng, J.
Deposit date:2014-08-19
Release date:2014-12-31
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-function analysis of vaccinia virus h7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication.
J.Virol., 89, 2015
8H5E
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BU of 8h5e by Molmil
Crystal structure of the MgtE TM domain in complex with Ca2+ ions at 2.5 angstrom resolution
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, Magnesium transporter MgtE
Authors:Teng, X, Sheng, D, Hattori, M.
Deposit date:2022-10-13
Release date:2022-12-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ion selectivity mechanism of the MgtE channel for Mg 2+ over Ca 2 .
Iscience, 25, 2022
7NWI
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BU of 7nwi by Molmil
Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA+BlaS, 40S ribosomal protein S11, ...
Authors:Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C.
Deposit date:2021-03-16
Release date:2021-07-07
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
7NWG
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BU of 7nwg by Molmil
Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.
Descriptor: 18S Ribosomal RNA, 28S Ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C.
Deposit date:2021-03-16
Release date:2021-07-07
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
7NWH
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BU of 7nwh by Molmil
Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S.
Descriptor: 18S Ribosomal RNA, 28S Ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C.
Deposit date:2021-03-16
Release date:2021-07-07
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
2VSN
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BU of 2vsn by Molmil
Structure and topological arrangement of an O-GlcNAc transferase homolog: insight into molecular control of intracellular glycosylation
Descriptor: URIDINE-5'-DIPHOSPHATE, XCOGT
Authors:Martinez-Fleites, C, Macauley, M.S, He, Y, Shen, D, Vocadlo, D, Davies, G.J.
Deposit date:2008-04-28
Release date:2008-06-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of an O-Glcnac Transferase Homolog Provides Insight Into Intracellular Glycosylation.
Nat.Struct.Mol.Biol., 15, 2008
4D3E
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BU of 4d3e by Molmil
Tetramer of IpaD, modified from 2J0O, fitted into negative stain electron microscopy reconstruction of the wild type tip complex from the type III secretion system of Shigella flexneri
Descriptor: INVASIN IPAD
Authors:Cheung, M, Shen, D.-K, Makino, F, Kato, T, Roehrich, D, Martinez-Argudo, I, Walker, M.L, Murillo, I, Liu, X, Pain, M, Brown, J, Frazer, G, Mantell, J, Mina, P, Todd, T, Sessions, R.B, Namba, K, Blocker, A.J.
Deposit date:2014-10-21
Release date:2014-12-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (24 Å)
Cite:Three-Dimensional Electron Microscopy Reconstruction and Cysteine-Mediated Crosslinking Provide a Model of the T3Ss Needle Tip Complex.
Mol.Microbiol., 95, 2015
7TS0
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BU of 7ts0 by Molmil
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein
Descriptor: Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Human corticotropin releasing factor receptor 2, Dominant negative Go alpha subunit, G protein gamma subunit, ...
Authors:Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E.
Deposit date:2022-01-31
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.
Nat Commun, 13, 2022
7TRY
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BU of 7try by Molmil
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein
Descriptor: Corticotropin-releasing factor receptor 2, G protein gamma subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E.
Deposit date:2022-01-31
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.
Nat Commun, 13, 2022
8JV5
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BU of 8jv5 by Molmil
Cryo-EM structure of the zebrafish P2X4 receptor in complex with BX430
Descriptor: 1-[2,6-bis(bromanyl)-4-propan-2-yl-phenyl]-3-pyridin-3-yl-urea, 2-acetamido-2-deoxy-beta-D-glucopyranose, P2X purinoceptor
Authors:Hattori, M, Shen, C.
Deposit date:2023-06-27
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural insights into the allosteric inhibition of P2X4 receptors.
Nat Commun, 14, 2023
8JV6
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BU of 8jv6 by Molmil
Cryo-EM structure of the zebrafish P2X4 receptor in complex with BAY-1797
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[4-(3-chloranylphenoxy)-3-sulfamoyl-phenyl]-2-phenyl-ethanamide, P2X purinoceptor
Authors:Hattori, M, Shen, C.
Deposit date:2023-06-27
Release date:2023-10-18
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structural insights into the allosteric inhibition of P2X4 receptors.
Nat Commun, 14, 2023
7VLA
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BU of 7vla by Molmil
Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex
Descriptor: C-C chemokine receptor type 1, CCL15(27-92), CHOLESTEROL, ...
Authors:Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H.
Deposit date:2021-10-02
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
8YUV
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BU of 8yuv by Molmil
Cryo-EM structure of the immepip-bound H3R-Gi complex
Descriptor: 4-(1H-imidazol-5-ylmethyl)piperidine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y.
Deposit date:2024-03-27
Release date:2024-06-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
Adv Sci, 11, 2024
8YUU
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BU of 8yuu by Molmil
Cryo-EM structure of the histamine-bound H3R-Gi complex
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y.
Deposit date:2024-03-27
Release date:2024-06-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
Adv Sci, 11, 2024
8YUT
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Cryo-EM structure of the amthamine-bound H2R-Gs complex
Descriptor: 5-(2-azanylethyl)-4-methyl-1,3-thiazol-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y.
Deposit date:2024-03-27
Release date:2024-06-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
Adv Sci, 11, 2024
7DFG
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BU of 7dfg by Molmil
Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir
Descriptor: 6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide, MAGNESIUM ION, Non-structural protein 7, ...
Authors:Li, Z, Zhou, Z, Yu, X.
Deposit date:2020-11-08
Release date:2021-11-17
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for repurpose and design of nucleotide drugs for treating COVID-19
To Be Published

 

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