7TRY

Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein

Summary for 7TRY

Entry DOI	10.2210/pdb7try/pdb
EMDB information	26103 26104
Descriptor	Corticotropin-releasing factor receptor 2, Urocortin, Guanine nucleotide-binding protein subunit alpha-11, ... (6 entities in total)
Functional Keywords	gpcr, corticotropin releasing factor receptor 2, urocortin 1, g11 protein, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	187680.06
Authors	Zhao, L.-H.,Lin, J.,Mao, C.,Zhou, X.E.,Ji, S.,Shen, D.,Xiao, P.,Melcher, K.,Zhang, Y.,Yu, X.,Xu, H.E. (deposition date: 2022-01-31, release date: 2022-11-09, Last modification date: 2022-11-16)
Primary citation	Zhao, L.H.,Lin, J.,Ji, S.Y.,Zhou, X.E.,Mao, C.,Shen, D.D.,He, X.,Xiao, P.,Sun, J.,Melcher, K.,Zhang, Y.,Yu, X.,Xu, H.E. Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor. Nat Commun, 13:6670-6670, 2022 Cited by PubMed: 36335102 DOI: 10.1038/s41467-022-33851-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation