7TS0
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein
Summary for 7TS0
Entry DOI | 10.2210/pdb7ts0/pdb |
EMDB information | 26103 26104 |
Descriptor | Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Human corticotropin releasing factor receptor 2, Urocortin, Dominant negative Go alpha subunit, ... (6 entities in total) |
Functional Keywords | gpcr, corticotropin releasing factor receptor 2, urocortin 1, go protein, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 186297.20 |
Authors | Zhao, L.-H.,Lin, J.,Mao, C.,Zhou, X.E.,Ji, S.,Shen, D.,Xiao, P.,Melcher, K.,Zhang, Y.,Yu, X.,Xu, H.E. (deposition date: 2022-01-31, release date: 2022-11-09, Last modification date: 2022-11-16) |
Primary citation | Zhao, L.H.,Lin, J.,Ji, S.Y.,Zhou, X.E.,Mao, C.,Shen, D.D.,He, X.,Xiao, P.,Sun, J.,Melcher, K.,Zhang, Y.,Yu, X.,Xu, H.E. Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor. Nat Commun, 13:6670-6670, 2022 Cited by PubMed: 36335102DOI: 10.1038/s41467-022-33851-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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