7VLA

Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex

Summary for 7VLA

• Entry DOI: 10.2210/pdb7vla/pdb
• EMDB information: 32022
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, ccr1, chemokine receptor, membrne protein, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 164152.53

Authors

Shao, Z.,Shen, Q.,Mao, C.,Yao, B.,Chen, L.,Zhang, H.,Shen, D.,Zhang, C.,Li, W.,Du, X.,Li, F.,Ma, H.,Chen, Z.,Xu, H.E.,Ying, S.,Zhang, Y.,Shen, H. (deposition date: 2021-10-02, release date: 2022-03-23)

• Primary citation: Shao, Z.,Shen, Q.,Yao, B.,Mao, C.,Chen, L.N.,Zhang, H.,Shen, D.D.,Zhang, C.,Li, W.,Du, X.,Li, F.,Ma, H.,Chen, Z.H.,Xu, H.E.,Ying, S.,Zhang, Y.,Shen, H.; Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.; Nat.Chem.Biol., 18:264-271, 2022; PubMed: 34949837; DOI: 10.1038/s41589-021-00918-z

Experimental method

ELECTRON MICROSCOPY (2.7 Å)