8YUU

Cryo-EM structure of the histamine-bound H3R-Gi complex

Summary for 8YUU

• Entry DOI: 10.2210/pdb8yuu/pdb
• EMDB information: 39583
• Descriptor: Histamine H3 receptor, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• Functional Keywords: gpcr, h3r, histamine receptor, membrane protein/immune system, membrane protein-immune system complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 167607.35

Authors

Shen, Q.,Tang, X.,Wen, X.,Cheng, S.,Xiao, P.,Zang, S.,Shen, D.,Jiang, L.,Zheng, Y.,Zhang, H.,Xu, H.,Mao, C.,Zhang, M.,Hu, W.,Sun, J.,Chen, Z.,Zhang, Y. (deposition date: 2024-03-27, release date: 2024-06-05, Last modification date: 2024-07-03)

• Primary citation: Shen, Q.,Tang, X.,Wen, X.,Cheng, S.,Xiao, P.,Zang, S.K.,Shen, D.D.,Jiang, L.,Zheng, Y.,Zhang, H.,Xu, H.,Mao, C.,Zhang, M.,Hu, W.,Sun, J.P.,Zhang, Y.,Chen, Z.; Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.; Adv Sci, 11:e2310120-e2310120, 2024; PubMed: 38647423; DOI: 10.1002/advs.202310120

Experimental method

ELECTRON MICROSCOPY (2.7 Å)