5KDO
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![BU of 5kdo by Molmil](/molmil-images/mine/5kdo) | Heterotrimeric complex of the 4 alanine insertion variant of the Gi alpha1 subunit and the Gbeta1-Ggamma1 | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... | 著者 | Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. | 登録日 | 2016-06-08 | 公開日 | 2016-08-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor. J.Biol.Chem., 291, 2016
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4KFM
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2BCJ
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1OMW
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![BU of 1omw by Molmil](/molmil-images/mine/1omw) | Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits | 分子名称: | G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1 | 著者 | Lodowski, D.T, Pitcher, J.A, Capel, W.D, Lefkowitz, R.J, Tesmer, J.J.G. | 登録日 | 2003-02-26 | 公開日 | 2003-06-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Keeping G proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and G-Beta-Gamma Science, 300, 2003
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5VAI
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![BU of 5vai by Molmil](/molmil-images/mine/5vai) | Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein | 分子名称: | Glucagon-like peptide 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, Y, Sun, B, Feng, D, Hu, H, Chu, M, Qu, Q, Tarrasch, J.T, Li, S, Kobilka, T.S, Kobilka, B.K, Skiniotis, G. | 登録日 | 2017-03-27 | 公開日 | 2017-05-24 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature, 546, 2017
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5UKL
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![BU of 5ukl by Molmil](/molmil-images/mine/5ukl) | Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd) | 分子名称: | 2-{5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-N-[2-(1H-pyrazol-4-yl)ethyl]acetamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cato, M.C, Homan, K.T, Tesmer, J.J.G. | 登録日 | 2017-01-23 | 公開日 | 2017-04-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J. Med. Chem., 60, 2017
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6CRK
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![BU of 6crk by Molmil](/molmil-images/mine/6crk) | Heterotrimeric G-protein in complex with an antibody fragment | 分子名称: | CITRATE ANION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Maeda, S, Dawson, R, Kobilka, B. | 登録日 | 2018-03-19 | 公開日 | 2018-10-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun, 9, 2018
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6P9Y
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![BU of 6p9y by Molmil](/molmil-images/mine/6p9y) | PAC1 GPCR Receptor complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. | 登録日 | 2019-06-10 | 公開日 | 2020-02-05 | 最終更新日 | 2020-02-19 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation. Mol.Cell, 77, 2020
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6PB1
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![BU of 6pb1 by Molmil](/molmil-images/mine/6pb1) | Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35 | 分子名称: | CHOLESTEROL, Corticotropin-releasing factor receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E. | 登録日 | 2019-06-12 | 公開日 | 2020-02-12 | 最終更新日 | 2020-02-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Mol.Cell, 77, 2020
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6CMO
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![BU of 6cmo by Molmil](/molmil-images/mine/6cmo) | Rhodopsin-Gi complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... | 著者 | Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. | 登録日 | 2018-03-05 | 公開日 | 2018-06-20 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature, 558, 2018
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7BW0
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![BU of 7bw0 by Molmil](/molmil-images/mine/7bw0) | Active human TGR5 complex with a synthetic agonist 23H | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Chen, G, Wang, X.K, Chen, Q, Hu, H.L, Ren, R.B. | 登録日 | 2020-04-12 | 公開日 | 2020-09-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther, 5, 2020
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7BZ2
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![BU of 7bz2 by Molmil](/molmil-images/mine/7bz2) | Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex. | 分子名称: | Beta2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, Y.N, Yang, F, Ling, S.L, Lv, P, Zhou, Y.X, Fang, W, Sun, W, Shi, P, Tian, C.L. | 登録日 | 2020-04-26 | 公開日 | 2020-08-05 | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | 主引用文献 | Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol. Cell Discov, 6, 2020
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6GDG
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![BU of 6gdg by Molmil](/molmil-images/mine/6gdg) | Cryo-EM structure of the adenosine A2A receptor bound to a miniGs heterotrimer | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Garcia-Nafria, J, Lee, Y. | 登録日 | 2018-04-23 | 公開日 | 2018-05-16 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.11 Å) | 主引用文献 | Cryo-EM structure of the adenosine A2Areceptor coupled to an engineered heterotrimeric G protein. Elife, 7, 2018
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7AD3
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4PNK
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![BU of 4pnk by Molmil](/molmil-images/mine/4pnk) | G protein-coupled receptor kinase 2 in complex with GSK180736A | 分子名称: | (4S)-4-(4-fluorophenyl)-N-(2H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Homan, K.T, Larimore, K.M, Elkins, J, Knapp, S, Tesmer, J.J.G. | 登録日 | 2014-05-23 | 公開日 | 2014-10-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors. Acs Chem.Biol., 10, 2015
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3CIK
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![BU of 3cik by Molmil](/molmil-images/mine/3cik) | Human GRK2 in Complex with Gbetagamma subunits | 分子名称: | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Tesmer, J.J.G, Lodowski, D.T. | 登録日 | 2008-03-11 | 公開日 | 2009-02-17 | 最終更新日 | 2012-03-07 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J.Med.Chem., 53, 2010
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2PBI
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![BU of 2pbi by Molmil](/molmil-images/mine/2pbi) | The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure | 分子名称: | GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9 | 著者 | Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J. | 登録日 | 2007-03-28 | 公開日 | 2008-01-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat.Struct.Mol.Biol., 15, 2008
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6G79
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![BU of 6g79 by Molmil](/molmil-images/mine/6g79) | Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor | 分子名称: | 2-[5-[2-[4-(4-cyanophenyl)piperazin-1-yl]-2-oxidanylidene-ethoxy]-1~{H}-indol-3-yl]ethylazanium, 5-hydroxytryptamine receptor 1B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Garcia-Nafria, J, Nehme, R, Edwards, P, Tate, C.G. | 登録日 | 2018-04-05 | 公開日 | 2018-06-20 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Cryo-EM structure of the serotonin 5-HT1Breceptor coupled to heterotrimeric Go. Nature, 558, 2018
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3KRW
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7AUE
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![BU of 7aue by Molmil](/molmil-images/mine/7aue) | Melanocortin receptor 4 (MC4R) Gs protein complex | 分子名称: | AMINOSERINE, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Degtjarik, O, Israeli, H, Prabahar, V, Shalev-Benami, M. | 登録日 | 2020-11-02 | 公開日 | 2021-04-28 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. Science, 372, 2021
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2TRC
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![BU of 2trc by Molmil](/molmil-images/mine/2trc) | PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX | 分子名称: | GADOLINIUM ATOM, PHOSDUCIN, TRANSDUCIN | 著者 | Gaudet, R, Bohm, A, Sigler, P.B. | 登録日 | 1997-01-06 | 公開日 | 1997-06-05 | 最終更新日 | 2019-08-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell(Cambridge,Mass.), 87, 1996
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3KRX
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1TBG
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![BU of 1tbg by Molmil](/molmil-images/mine/1tbg) | BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN | 分子名称: | TRANSDUCIN | 著者 | Sondek, J.S, Bohm, A, Lambright, D.G, Hamm, H.E, Sigler, P.B. | 登録日 | 1996-06-15 | 公開日 | 1997-04-01 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature, 379, 1996
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4MK0
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1XHM
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![BU of 1xhm by Molmil](/molmil-images/mine/1xhm) | The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1, SIGK Peptide | 著者 | Davis, T.L, Bonacci, T.M, Smrcka, A.V, Sprang, S.R. | 登録日 | 2004-09-20 | 公開日 | 2005-08-09 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and Molecular Characterization of a Preferred Protein Interaction Surface on G Protein betagamma Subunits. Biochemistry, 44, 2005
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