3KRX

Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)

Summary for 3KRX

Related1OMW 3CIK 1BX6 3KRW
DescriptorBeta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywordsrgs homology domain, atp-binding, phosphoprotein, serine/threonine-protein kinase, transferase, transducer, wd repeat, cell membrane, lipoprotein, membrane, methylation, prenylation, protein binding
Biological sourceHomo sapiens (human)
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Cellular locationCell membrane; Lipid-anchor; Cytoplasmic side (Potential) P63212
Total number of polymer chains3
Total molecular weight125959.85
Authors
Tesmer, J.J.G.,Tesmer, V.M. (deposition date: 2009-11-19, release date: 2010-02-16, Last modification date: 2011-07-13)
Primary citation
Tesmer, J.J.,Tesmer, V.M.,Lodowski, D.T.,Steinhagen, H.,Huber, J.
Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53:1867-1870, 2010
PubMed: 20128603 (PDB entries with the same primary citation)
DOI: 10.1021/jm9017515
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27260.3%2.5%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution