3KRX

Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Beta-adrenergic receptor kinase 1	polymer	688	79561.4	1	UniProt (P25098) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) In PDB	Homo sapiens (human)	Beta-ARK-1, G-protein coupled receptor kinase 2
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	340	37416.9	1	UniProt (P62871) Pfam (PF00400) In PDB	Bos taurus (bovine cow domestic cattle domestic cow)	Transducin beta chain 1
3	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	74	8406.7	1	UniProt (P63212) Pfam (PF00631) In PDB	Bos taurus (bovine cow domestic cattle domestic cow)	G gamma-I
4	A	BALANOL	non-polymer		550.5	1	Chemie (BA1)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6		water	water		18.0	3	Chemie (HOH)

Sequence modifications

G: 1 - 68 (UniProt: P63212)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	125385.0
Non-Polymers*	Number of molecules	2
	Total formula weight	574.8
All*	Total formula weight	125959.9

*Water molecules are not included.