3KRW
Human GRK2 in complex with Gbetgamma subunits and balanol (soak)
Summary for 3KRW
Entry DOI | 10.2210/pdb3krw/pdb |
Related | 1BX6 1OMW 3CIK 3KRX |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | protein kinase, inhibitor, complex, wd40, ph domain, rgs homology domain, atp-binding, kinase, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, acetylation, transducer, wd repeat, cell membrane, lipoprotein, membrane, methylation, prenylation, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212 |
Total number of polymer chains | 3 |
Total formula weight | 125959.85 |
Authors | Tesmer, J.J.G.,Tesmer, V.M. (deposition date: 2009-11-19, release date: 2010-02-16, Last modification date: 2023-09-06) |
Primary citation | Tesmer, J.J.,Tesmer, V.M.,Lodowski, D.T.,Steinhagen, H.,Huber, J. Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J.Med.Chem., 53:1867-1870, 2010 Cited by PubMed: 20128603DOI: 10.1021/jm9017515 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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