4PNK

G protein-coupled receptor kinase 2 in complex with GSK180736A

Summary for 4PNK

Related3V5W 4MK0 4PNI
DescriptorBeta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
Functional Keywordsprotein kinase, hydrolase, atp binding, phosphorylation, peripheral membrane protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm  P25098
Cell membrane ; Lipid-anchor ; Cytoplasmic side  P63212
Total number of polymer chains3
Total molecular weight125320.01
Authors
Homan, K.T.,Larimore, K.M.,Elkins, J.,Knapp, S.,Tesmer, J.J.G. (deposition date: 2014-05-23, release date: 2014-10-08, Last modification date: 2017-09-06)
Primary citation
Homan, K.T.,Larimore, K.M.,Elkins, J.M.,Szklarz, M.,Knapp, S.,Tesmer, J.J.
Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors.
Acs Chem.Biol., 10:310-319, 2015
PubMed: 25238254 (PDB entries with the same primary citation)
DOI: 10.1021/cb5006323
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.56 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25571.2%5.2%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution