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4PNK

G protein-coupled receptor kinase 2 in complex with GSK180736A

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0002026biological_processregulation of the force of heart contraction
A0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
A0003108biological_processnegative regulation of the force of heart contraction by chemical signal
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004703molecular_functionG protein-coupled receptor kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006468biological_processprotein phosphorylation
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007217biological_processtachykinin receptor signaling pathway
A0007507biological_processheart development
A0016020cellular_componentmembrane
A0016310biological_processphosphorylation
A0018105biological_processpeptidyl-serine phosphorylation
A0019079biological_processviral genome replication
A0031623biological_processreceptor internalization
A0031694molecular_functionalpha-2A adrenergic receptor binding
A0031755molecular_functionEdg-2 lysophosphatidic acid receptor binding
A0032473cellular_componentcytoplasmic side of mitochondrial outer membrane
A0033605biological_processpositive regulation of catecholamine secretion
A0042995cellular_componentcell projection
A0045202cellular_componentsynapse
A0045988biological_processnegative regulation of striated muscle contraction
A0046718biological_processsymbiont entry into host cell
A0047696molecular_functionbeta-adrenergic receptor kinase activity
A0060048biological_processcardiac muscle contraction
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A1901081biological_processnegative regulation of relaxation of smooth muscle
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue KZQ A 701
ChainResidue
AILE197
AALA321
AASN322
ALEU324
ASER334
AGLY198
AARG199
AGLY200
AVAL205
AALA218
ALEU222
AASP272
AMET274

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK
ChainResidueDetails
AILE197-LYS220

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL
ChainResidueDetails
AVAL313-LEU325

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7626050
ChainResidueDetails
GALA2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:1903391
ChainResidueDetails
GSER68
ALYS220

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:12764189, ECO:0000269|PubMed:1903391, ECO:0000269|PubMed:7626050
ChainResidueDetails
GSER68
ALEU4
AASP10

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER670

226707

PDB entries from 2024-10-30

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