4PNK
G protein-coupled receptor kinase 2 in complex with GSK180736A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-adrenergic receptor kinase 1 | polymer | 689 | 79692.6 | 1 | UniProt (P25098) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) | Homo sapiens (Human) | Beta-ARK-1,G-protein coupled receptor kinase 2 |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (Bovine) | G gamma-I |
| 4 | D (A) | (4S)-4-(4-fluorophenyl)-N-(2H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide | non-polymer | 365.4 | 1 | Chemie (KZQ) | |||
| 5 | E, F, G (A, B, G) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
G: 1 - 71 (UniProt: P63212)
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 124954.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 365.4 | |
| All* | Total formula weight | 125320.0 |
