3V5W
Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine
Summary for 3V5W
Entry DOI | 10.2210/pdb3v5w/pdb |
Related | 3CIK 3KRW 3PVU 3PVW |
Descriptor | G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | inhibitor complex, protein kinase, beta propeller, rgs homology domain, pleckstrin homology domain, kinase, signal transduction, peripheral membrane protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212 |
Total number of polymer chains | 3 |
Total formula weight | 126137.20 |
Authors | Thal, D.M.,Tesmer, J.J.G. (deposition date: 2011-12-17, release date: 2012-09-26, Last modification date: 2023-09-13) |
Primary citation | Thal, D.M.,Homan, K.T.,Chen, J.,Wu, E.K.,Hinkle, P.M.,Huang, Z.M.,Chuprun, J.K.,Song, J.,Gao, E.,Cheung, J.Y.,Sklar, L.A.,Koch, W.J.,Tesmer, J.J. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. Acs Chem.Biol., 7:1830-1839, 2012 Cited by PubMed: 22882301DOI: 10.1021/cb3003013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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