3PVU

Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)

Summary for 3PVU

Entry DOI	10.2210/pdb3pvu/pdb
Related	1OMW 3CIK 3KRW 3KRX 3PSC 3PVW
Descriptor	Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
Functional Keywords	transferase, serine/threonine-protein kinase, atp-binding, inhibitor, membrane, transferase-signaling protein-inhibitor complex, transferase/signaling protein/inhibitor
Biological source	Bos taurus (bovine) More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212
Total number of polymer chains	3
Total formula weight	126868.87
Authors	Thal, D.M.,Tesmer, J.J. (deposition date: 2010-12-07, release date: 2011-06-01, Last modification date: 2023-09-06)
Primary citation	Thal, D.M.,Yeow, R.Y.,Schoenau, C.,Huber, J.,Tesmer, J.J. Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol.Pharmacol., 80:294-303, 2011 Cited by PubMed: 21596927 DOI: 10.1124/mol.111.071522 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation