3CIK

Human GRK2 in Complex with Gbetagamma subunits

Summary for 3CIK

Entry DOI	10.2210/pdb3cik/pdb
Related	1BX6 1OMW 3CIL
Descriptor	Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
Functional Keywords	protein kinase, complex, g protein, receptor, wd40 repeat, atp-binding, nucleotide-binding, serine/threonine-protein kinase, transferase, transducer, wd repeat, lipoprotein, membrane, phosphoprotein, prenylation, transferase-signaling protein complex, transferase/signaling protein
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212
Total number of polymer chains	3
Total formula weight	125540.53
Authors	Tesmer, J.J.G.,Lodowski, D.T. (deposition date: 2008-03-11, release date: 2009-02-17, Last modification date: 2012-03-07)
Primary citation	Tesmer, J.J.,Tesmer, V.M.,Lodowski, D.T.,Steinhagen, H.,Huber, J. Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J.Med.Chem., 53:1867-1870, 2010 Cited by PubMed: 20128603 DOI: 10.1021/jm9017515 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation