3V5W

Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	G-protein coupled receptor kinase 2	polymer	689	79692.6	1	UniProt (P25098) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) In PDB	Homo sapiens (human)	Beta-ARK-1, Beta-adrenergic receptor kinase 1
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	340	37416.9	1	UniProt (P62871) Pfam (PF00400) In PDB	Bos taurus (bovine)	Transducin beta chain 1
3	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	77	8674.0	1	UniProt (P63212) Pfam (PF00631) In PDB	Bos taurus (bovine)	G gamma-I
4	A	Paroxetine	non-polymer		329.4	1	Chemie (8PR)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6		water	water		18.0	296	Chemie (HOH)

Sequence modifications

G: 1 - 71 (UniProt: P63212)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 68	Cys 68	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	125783.5
Non-Polymers*	Number of molecules	2
	Total formula weight	353.7
All*	Total formula weight	126137.2

*Water molecules are not included.