4PNI

Bovine G protein-coupled receptor kinase 1 in complex with GSK2163632A

Summary for 4PNI

Entry DOI	10.2210/pdb4pni/pdb
Related	4L9I 4PNK
Descriptor	Rhodopsin kinase, 3-[(2-{[1-(N,N-dimethylglycyl)-6-methoxy-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]thiophene-2-carboxamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	agc family kinase, ser/thr kinase, rgs homology domain, g protein coupled receptor kinase, grk, grk1, rhodopsin kinase, hydrolyase, gpcr, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Bos taurus (Bovine)
Total number of polymer chains	1
Total formula weight	63773.20
Authors	Homan, K.T.,Tesmer, J.J.G. (deposition date: 2014-05-23, release date: 2014-10-08, Last modification date: 2023-12-27)
Primary citation	Homan, K.T.,Larimore, K.M.,Elkins, J.M.,Szklarz, M.,Knapp, S.,Tesmer, J.J. Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors. Acs Chem.Biol., 10:310-319, 2015 Cited by PubMed: 25238254 DOI: 10.1021/cb5006323 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation