4PNI

Bovine G protein-coupled receptor kinase 1 in complex with GSK2163632A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001750	cellular_component	photoreceptor outer segment
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004703	molecular_function	G protein-coupled receptor kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
A	0007601	biological_process	visual perception
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0022400	biological_process	regulation of opsin-mediated signaling pathway
A	0050254	molecular_function	rhodopsin kinase activity
A	0097381	cellular_component	photoreceptor disc membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue KQQ A 601

Chain	Residue
A	LEU193
A	ARG474
A	THR475
A	PHE198
A	ALA214
A	THR265
A	MET267
A	ASN268
A	GLY270
A	ASP271
A	LEU321

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 602

Chain	Residue
A	LEU166
A	ARG170
A	GLN173

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 603

Chain	Residue
A	GLN287
A	ARG290

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 604

Chain	Residue
A	ARG386
A	PHE389
A	GLN408
A	ARG453

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 605

Chain	Residue
A	TRP457
A	ARG458

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CL A 606

Chain	Residue
A	GLY387
A	PRO388
A	PHE389
A	ARG390
A	HOH846

---

site_id	AC7
Number of Residues	1
Details	binding site for residue CL A 607

Chain	Residue
A	LYS90

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGGFGEVFaCqmkatgkl..........YACK

Chain	Residue	Details
A	LEU193-LYS216

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNVLL

Chain	Residue	Details
A	ILE310-LEU322

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	114
Details	Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	265
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---