4L9I

Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine

Summary for 4L9I

Entry DOI	10.2210/pdb4l9i/pdb
Related	3C50 3V5W 4MK0
Descriptor	Rhodopsin kinase, Paroxetine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords	agc family kinase, ser/thr kinase, rgs homology domain, g protein coupled receptor kinase, grk, grk1, rhodopsin kinase, ssri, hydrolyase, gpcr, phosphorylation, transferase, membrane protein-inhibitor complex, membrane protein/inhibitor
Biological source	Bos taurus (bovine)
Cellular location	Membrane ; Lipid- anchor : P28327
Total number of polymer chains	2
Total formula weight	115635.99
Authors	Homan, K.T.,Tesmer, J.J.G. (deposition date: 2013-06-18, release date: 2014-01-22, Last modification date: 2023-09-20)
Primary citation	Homan, K.T.,Wu, E.,Wilson, M.W.,Singh, P.,Larsen, S.D.,Tesmer, J.J. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol.Pharmacol., 85:237-248, 2014 Cited by PubMed: 24220010 DOI: 10.1124/mol.113.089631 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.32 Å)

Structure validation