4L9I
Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001750 | cellular_component | photoreceptor outer segment |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0004703 | molecular_function | G protein-coupled receptor kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0006468 | biological_process | protein phosphorylation |
A | 0007165 | biological_process | signal transduction |
A | 0007601 | biological_process | visual perception |
A | 0009966 | biological_process | regulation of signal transduction |
A | 0016020 | cellular_component | membrane |
A | 0016310 | biological_process | phosphorylation |
A | 0022400 | biological_process | regulation of opsin-mediated signaling pathway |
A | 0042995 | cellular_component | cell projection |
A | 0046777 | biological_process | protein autophosphorylation |
A | 0050254 | molecular_function | rhodopsin kinase activity |
A | 0097381 | cellular_component | photoreceptor disc membrane |
B | 0001750 | cellular_component | photoreceptor outer segment |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0004703 | molecular_function | G protein-coupled receptor kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0006468 | biological_process | protein phosphorylation |
B | 0007165 | biological_process | signal transduction |
B | 0007601 | biological_process | visual perception |
B | 0009966 | biological_process | regulation of signal transduction |
B | 0016020 | cellular_component | membrane |
B | 0016310 | biological_process | phosphorylation |
B | 0022400 | biological_process | regulation of opsin-mediated signaling pathway |
B | 0042995 | cellular_component | cell projection |
B | 0046777 | biological_process | protein autophosphorylation |
B | 0050254 | molecular_function | rhodopsin kinase activity |
B | 0097381 | cellular_component | photoreceptor disc membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 8PR A 601 |
Chain | Residue |
A | GLY194 |
A | ASP271 |
A | GLU318 |
A | LEU321 |
A | ARG195 |
A | GLY196 |
A | GLY199 |
A | VAL201 |
A | ALA214 |
A | LEU218 |
A | THR265 |
A | MET267 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MES A 602 |
Chain | Residue |
A | ASP127 |
A | ALA128 |
A | GLU129 |
A | GLY348 |
A | TYR349 |
A | ALA350 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 8PR B 601 |
Chain | Residue |
B | GLY194 |
B | ARG195 |
B | GLY196 |
B | GLY199 |
B | VAL201 |
B | ALA214 |
B | THR265 |
B | MET267 |
B | ASP271 |
B | GLU318 |
B | LEU321 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL B 602 |
Chain | Residue |
A | GLN173 |
B | LEU166 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL B 603 |
Chain | Residue |
A | SER165 |
A | LEU166 |
B | ARG170 |
B | GLN173 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGGFGEVFaCqmkatgkl..........YACK |
Chain | Residue | Details |
A | LEU193-LYS216 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNVLL |
Chain | Residue | Details |
A | ILE310-LEU322 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
A | ASP314 | |
B | ASP314 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | LEU193 | |
B | LEU193 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LYS216 | |
B | LYS216 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | THR265 | |
A | ASP332 | |
B | THR265 | |
B | ASP332 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:1527025, ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | SER488 | |
B | SER488 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:1527025, ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | THR489 | |
B | THR489 |