4MK0
Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
Summary for 4MK0
Entry DOI | 10.2210/pdb4mk0/pdb |
Related | 1OMW 3V5W 4L9I |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | inhibitor complex, protein kinase, hydrolase, atp binding, phosphorylation, peripheral membrane protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm : P25098 Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212 |
Total number of polymer chains | 3 |
Total formula weight | 118781.37 |
Authors | Homan, K.T.,Tesmer, J.J.G. (deposition date: 2013-09-04, release date: 2014-01-22, Last modification date: 2024-02-28) |
Primary citation | Homan, K.T.,Wu, E.,Wilson, M.W.,Singh, P.,Larsen, S.D.,Tesmer, J.J. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol.Pharmacol., 85:237-248, 2014 Cited by PubMed: 24220010DOI: 10.1124/mol.113.089631 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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