4MK0
Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-adrenergic receptor kinase 1 | polymer | 640 | 74545.6 | 1 | UniProt (P25098) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) | Homo sapiens (human) | Beta-ARK-1, G-protein coupled receptor kinase 2 |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62871) Pfam (PF00400) | Bos taurus (cow) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 59 | 6519.5 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (cow) | G gamma-I |
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | 5-{[(3S,4R)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-1H-isoindol-1-one | non-polymer | 338.4 | 1 | Chemie (29X) | |||
| 6 | F, G, H (A, B, G) | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A: 30 - 668 (UniProt: P25098)
| PDB | External Database | Details |
|---|---|---|
| Ala 669 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118350.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 430.5 | |
| All* | Total formula weight | 118781.4 |
