Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex

Summary for 3UZS

Related3UZT 1OMW
DescriptorBeta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
Functional Keywordsprotein-rna complex, protein kinase fold, rgs homology domain, pleckstrin homology domain, beta propeller, g protein-coupled receptor phosphorylation, rna aptamer, carboxymethylation, geranylgeranylation, transferase-rna complex, transferase/rna
Biological sourceBos taurus (bovine)
Cellular locationCell membrane; Lipid-anchor; Cytoplasmic side (Potential) P63212
Total number of polymer chains4
Total molecular weight134677.33
Tesmer, J.J.G.,Tesmer, V.M. (deposition date: 2011-12-07, release date: 2012-07-11, Last modification date: 2012-08-29)
Primary citation
Tesmer, V.M.,Lennarz, S.,Mayer, G.,Tesmer, J.J.
Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer.
Structure, 20:1300-1309, 2012
PubMed: 22727813 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2012.05.002
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone 0.26110 1.9% 4.0% 0.4% 0.37MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-28