Heterotrimeric complex of the 4 alanine insertion variant of the Gi alpha1 subunit and the Gbeta1-Ggamma1

Summary for 5KDO

DescriptorGuanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... (5 entities in total)
Functional Keywordsheterotrimeric g protein g protein coupled receptors g protein activation g protein structure gdp release, signaling protein
Biological sourceRattus norvegicus (Rat)
Cellular locationNucleus P10824
Cell membrane ; Lipid-anchor ; Cytoplasmic side  P02698
Total number of polymer chains3
Total molecular weight87100.4
Kaya, A.I.,Lokits, A.D.,Gilbert, J.,Iverson, T.M.,Meiler, J.,Hamm, H.E. (deposition date: 2016-06-08, release date: 2016-08-03, Last modification date: 2017-09-13)
Primary citation
Kaya, A.I.,Lokits, A.D.,Gilbert, J.A.,Iverson, T.M.,Meiler, J.,Hamm, H.E.
A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291:19674-19686, 2016
PubMed: 27462082 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M116.745513
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.222400.2%6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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