5TDH
The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S
Summary for 5TDH
Entry DOI | 10.2210/pdb5tdh/pdb |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (4 entities in total) |
Functional Keywords | dominant negative, g-alpha(i)-1-beta-1-gamma-2 heterotrimer, g203a, a326s, gpcr, gdp, cell cycle |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P63096 Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212 |
Total number of polymer chains | 6 |
Total formula weight | 172022.18 |
Authors | Liu, P.,Jia, M.-Z.,Zhou, X.E.,de Waal, P.W.,Dickson, B.M.,Liu, B.,Hou, L.,Yin, Y.-T.,Kang, Y.-Y.,Shi, Y.,Melcher, K.,Xu, H.E.,Jiang, Y. (deposition date: 2016-09-19, release date: 2016-11-09, Last modification date: 2024-03-20) |
Primary citation | Liu, P.,Jia, M.-Z.,Zhou, X.E.,De Waal, P.W.,Dickson, B.M.,Liu, B.,Hou, L.,Yin, Y.-T.,Kang, Y.-Y.,Shi, Y.,Melcher, K.,Xu, H.E.,Jiang, Y. The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer Acta Pharmacol.Sin., 37:1259-1272, 2016 Cited by PubMed: 27498775DOI: 10.1038/aps.2016.69 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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