6B3J

3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

Summary for 6B3J

• Entry DOI: 10.2210/pdb6b3j/pdb
• EMDB information: 7039
• Descriptor: Glucagon-like peptide 1 receptor, Exendin-P5, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
• Functional Keywords: class b g protein-coupled receptor, agonist-receptor-g protein ternary complex, glucagon-like peptide 1 receptor, active-state g protein-coupled receptor, signaling protein, phase plate, phase contrast, single particle cryo-em
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 168196.47

Authors

Liang, Y.L.,Khoshouei, M.,Glukhova, A.,Furness, S.G.B.,Koole, C.,Zhao, P.,Clydesdale, L.,Thal, D.M.,Radjainia, M.,Danev, R.,Baumeister, W.,Wang, M.W.,Miller, L.J.,Christopoulos, A.,Sexton, P.M.,Wootten, D. (deposition date: 2017-09-22, release date: 2018-02-21, Last modification date: 2020-01-15)

• Primary citation: Liang, Y.L.,Khoshouei, M.,Glukhova, A.,Furness, S.G.B.,Zhao, P.,Clydesdale, L.,Koole, C.,Truong, T.T.,Thal, D.M.,Lei, S.,Radjainia, M.,Danev, R.,Baumeister, W.,Wang, M.W.,Miller, L.J.,Christopoulos, A.,Sexton, P.M.,Wootten, D.; Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.; Nature, 555:121-125, 2018; PubMed: 29466332; DOI: 10.1038/nature25773

Experimental method

ELECTRON MICROSCOPY (3.3 Å)