4KFM

Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits

Summary for 4KFM

Entry DOI	10.2210/pdb4kfm/pdb
Related	3SYA 3SYC 3SYO 3SYP 3SYQ
Descriptor	G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywords	metal transport, ion channel, potassium channel, inward rectification, sodium binding, pip2 binding, g protein binding
Biological source	Mus musculus (mouse) More
Cellular location	Membrane; Multi-pass membrane protein (By similarity): Q8C4T8 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P59768
Total number of polymer chains	3
Total formula weight	85672.47
Authors	Whorton, M.R.,MacKinnon, R. (deposition date: 2013-04-27, release date: 2013-06-12, Last modification date: 2013-09-11)
Primary citation	Whorton, M.R.,MacKinnon, R. X-ray structure of the mammalian GIRK2-beta gamma G-protein complex. Nature, 498:190-197, 2013 Cited by PubMed: 23739333 DOI: 10.1038/nature12241 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.45 Å)

Structure validation