4KFM
Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | G protein-activated inward rectifier potassium channel 2 | polymer | 340 | 39062.0 | 1 | UniProt (Q8C4T8) Pfam (PF01007) Pfam (PF17655) UniProt (by SIFTS) (P48542) In PDB | Mus musculus (mouse) | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7717.9 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | A | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 1 | Chemie (PIO) | |||
5 | A | POTASSIUM ION | non-polymer | 39.1 | 5 | Chemie (K) | |||
6 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
7 | A | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) |
Sequence modifications
A: 52 - 380 (UniProt: Q8C4T8)
G: 1 - 68 (UniProt: P59768)
PDB | External Database | Details |
---|---|---|
Met 50 | - | EXPRESSION TAG |
Ala 51 | - | EXPRESSION TAG |
Ser 381 | - | EXPRESSION TAG |
Asn 382 | - | EXPRESSION TAG |
Ser 383 | - | EXPRESSION TAG |
Leu 384 | - | EXPRESSION TAG |
Glu 385 | - | EXPRESSION TAG |
Val 386 | - | EXPRESSION TAG |
Leu 387 | - | EXPRESSION TAG |
Phe 388 | - | EXPRESSION TAG |
Gln 389 | - | EXPRESSION TAG |
PDB | External Database | Details |
---|---|---|
Gly -1 | - | EXPRESSION TAG |
Pro 0 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 84196.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1475.7 | |
All* | Total formula weight | 85672.5 |