4KFM
Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005242 | molecular_function | inward rectifier potassium channel activity |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| B | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| B | 0007213 | biological_process | G protein-coupled acetylcholine receptor signaling pathway |
| B | 0007265 | biological_process | Ras protein signal transduction |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0016020 | cellular_component | membrane |
| B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045202 | cellular_component | synapse |
| B | 0050909 | biological_process | sensory perception of taste |
| B | 0051020 | molecular_function | GTPase binding |
| B | 0060041 | biological_process | retina development in camera-type eye |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| B | 0071870 | biological_process | cellular response to catecholamine stimulus |
| B | 0097381 | cellular_component | photoreceptor disc membrane |
| B | 1903561 | cellular_component | extracellular vesicle |
| G | 0005515 | molecular_function | protein binding |
| G | 0005834 | cellular_component | heterotrimeric G-protein complex |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0007165 | biological_process | signal transduction |
| G | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| G | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| G | 0016020 | cellular_component | membrane |
| G | 0031681 | molecular_function | G-protein beta-subunit binding |
| G | 0048144 | biological_process | fibroblast proliferation |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| G | 0071870 | biological_process | cellular response to catecholamine stimulus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PIO A 401 |
| Chain | Residue |
| A | LYS64 |
| A | LYS90 |
| A | TRP91 |
| A | ARG92 |
| A | LYS194 |
| A | LYS199 |
| A | LYS200 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE K A 402 |
| Chain | Residue |
| A | GLY156 |
| A | GLY156 |
| A | TYR157 |
| A | TYR157 |
| A | TYR157 |
| A | TYR157 |
| A | K403 |
| A | K403 |
| A | K403 |
| A | K403 |
| A | GLY156 |
| A | GLY156 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE K A 403 |
| Chain | Residue |
| A | ILE155 |
| A | ILE155 |
| A | ILE155 |
| A | ILE155 |
| A | K402 |
| A | K402 |
| A | K402 |
| A | K402 |
| A | K404 |
| A | K404 |
| A | K404 |
| A | K404 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE K A 404 |
| Chain | Residue |
| A | THR154 |
| A | THR154 |
| A | THR154 |
| A | THR154 |
| A | ILE155 |
| A | ILE155 |
| A | ILE155 |
| A | ILE155 |
| A | K403 |
| A | K403 |
| A | K403 |
| A | K403 |
| A | K405 |
| A | K405 |
| A | K405 |
| A | K405 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE K A 405 |
| Chain | Residue |
| A | THR154 |
| A | THR154 |
| A | THR154 |
| A | THR154 |
| A | K404 |
| A | K404 |
| A | K404 |
| A | K404 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 407 |
| Chain | Residue |
| A | ASP228 |
| A | ARG230 |
| A | SER232 |
| A | LEU275 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LMT A 408 |
| Chain | Residue |
| A | HIS68 |
| A | HIS69 |
| A | ASN231 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=M1 => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG92-ILE116 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 31 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA117-GLY140 | |
| A | ARG160-GLU168 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | INTRAMEM: Helical; Pore-forming; Name=H5 => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE141-GLU152 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | INTRAMEM: Pore-forming => ECO:0000250 |
| Chain | Residue | Details |
| A | THR153-TYR159 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=M2 => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY169-CYS190 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN184 |
