3AH8
Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890
Summary for 3AH8
Entry DOI | 10.2210/pdb3ah8/pdb |
Related PRD ID | PRD_000482 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1/Guanine nucleotide-binding protein G(q) subunit alpha chimeric protein, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total) |
Functional Keywords | heterotrimeric g protein, gtpase, galpha-q, gbeta, ggamma, inhibitor, ym-254890, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Rattus norvegicus (Rat, Mouse) More |
Cellular location | Nucleus : P21279 Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212 |
Total number of polymer chains | 4 |
Total formula weight | 88842.15 |
Authors | Nishimura, A.,Kitano, K.,Takasaki, J.,Taniguchi, M.,Mizuno, N.,Tago, K.,Hakoshima, T.,Itoh, H. (deposition date: 2010-04-20, release date: 2010-07-21, Last modification date: 2023-11-15) |
Primary citation | Nishimura, A.,Kitano, K.,Takasaki, J.,Taniguchi, M.,Mizuno, N.,Tago, K.,Hakoshima, T.,Itoh, H. Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc.Natl.Acad.Sci.USA, 107:13666-13671, 2010 Cited by PubMed: 20639466DOI: 10.1073/pnas.1003553107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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