3AH8

Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890

Summary for 3AH8

Entry DOI	10.2210/pdb3ah8/pdb
Related PRD ID	PRD_000482
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1/Guanine nucleotide-binding protein G(q) subunit alpha chimeric protein, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
Functional Keywords	heterotrimeric g protein, gtpase, galpha-q, gbeta, ggamma, inhibitor, ym-254890, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Rattus norvegicus (Rat, Mouse) More
Cellular location	Nucleus : P21279 Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212
Total number of polymer chains	4
Total formula weight	88842.15
Authors	Nishimura, A.,Kitano, K.,Takasaki, J.,Taniguchi, M.,Mizuno, N.,Tago, K.,Hakoshima, T.,Itoh, H. (deposition date: 2010-04-20, release date: 2010-07-21, Last modification date: 2023-11-15)
Primary citation	Nishimura, A.,Kitano, K.,Takasaki, J.,Taniguchi, M.,Mizuno, N.,Tago, K.,Hakoshima, T.,Itoh, H. Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc.Natl.Acad.Sci.USA, 107:13666-13671, 2010 Cited by PubMed: 20639466 DOI: 10.1073/pnas.1003553107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation