Ligand binding domain of human PPAR gamma in complex with amorfrutin 1

Summary for 2YFE

Related2FVJ 2VV2 1FM9 2XKW 2VV0 2VV1 2PRG 1KNU 1RDT 2VV4 3PRG 1I7I 1K74 1FM6 1ZGY 1PRG 2F4B 2VST 2G0H 2VSR 1WM0 4PRG 1NYX 2VV3 2G0G
DescriptorPEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, Amorfrutin 1 (3 entities in total)
Functional Keywordsreceptor, agonist, diabetes, insulin resistance
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight66068.47
de Groot, J.C.,Buessow, K. (deposition date: 2011-04-05, release date: 2012-04-11, Last modification date: 2012-05-23)
Primary citation
Weidner, C.,De Groot, J.C.,Prasad, A.,Freiwald, A.,Quedenau, C.,Kliem, M.,Witzke, A.,Kodelja, V.,Han, C.-T.,Giegold, S.,Baumann, M.,Klebl, B.,Siems, K.,Mueller-Kuhrt, L.,Schuermann, A.,Schueller, R.,Pfeiffer, A.F.H.,Schroeder, F.C.,Buessow, K.,Sauer, S.
Amorfrutins are Potent Antidiabetic Dietary Natural Products
Proc.Natl.Acad.Sci.USA, 109:7257-, 2012
PubMed: 22509006 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.1116971109
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.251604.4%7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report