2YFE

Ligand binding domain of human PPAR gamma in complex with amorfrutin 1

Summary for 2YFE

Related2FVJ 2VV2 1FM9 2XKW 2VV0 2VV1 2PRG 1KNU 1RDT 2VV4 3PRG 1I7I 1K74 1FM6 1ZGY 1PRG 2F4B 2VST 2G0H 2VSR 1WM0 4PRG 1NYX 2VV3 2G0G
DescriptorPEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, Amorfrutin 1 (3 entities in total)
Functional Keywordsreceptor, agonist, diabetes, insulin resistance
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight66068.47
Authors
de Groot, J.C.,Buessow, K. (deposition date: 2011-04-05, release date: 2012-04-11, Last modification date: 2012-05-23)
Primary citation
Weidner, C.,De Groot, J.C.,Prasad, A.,Freiwald, A.,Quedenau, C.,Kliem, M.,Witzke, A.,Kodelja, V.,Han, C.-T.,Giegold, S.,Baumann, M.,Klebl, B.,Siems, K.,Mueller-Kuhrt, L.,Schuermann, A.,Schueller, R.,Pfeiffer, A.F.H.,Schroeder, F.C.,Buessow, K.,Sauer, S.
Amorfrutins are Potent Antidiabetic Dietary Natural Products
Proc.Natl.Acad.Sci.USA, 109:7257-, 2012
PubMed: 22509006 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.1116971109
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.251604.4%7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report