2FVJ

A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro

Summary for 2FVJ

DescriptorPeroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-4-{[4-(2-METHOXYPHENYL)PIPERIDIN-1-YL]METHYL}ISOQUINOLINE, ... (5 entities in total)
Functional Keywordsnuclear receptor lbd, alpha helical sandwich, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Nucleus (By similarity) Q15788
Total number of polymer chains2
Total molecular weight33103.48
Authors
Benz, J.,Burgermeister, E.,Flament, A.,Schnoebelen, A.,Stihle, M.,Gsell, B.,Rufer, A.,Ruf, A.,Kuhn, B.,Maerki, H.P.,Mizrahi, J.,Sebokova, E.,Niesor, E.,Meyer, M. (deposition date: 2006-01-31, release date: 2006-05-16, Last modification date: 2011-07-13)
Primary citation
Burgermeister, E.,Schnoebelen, A.,Flament, A.,Benz, J.,Stihle, M.,Gsell, B.,Rufer, A.,Ruf, A.,Kuhn, B.,Maerki, H.P.,Mizrahi, J.,Sebokova, E.,Niesor, E.,Meyer, M.
A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro
Mol.Endocrinol., 20:809-830, 2006
PubMed: 16373399 (PDB entries with the same primary citation)
DOI: 10.1210/me.2005-0171
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.99 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24590.4%4.1%11.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report