2PRG

LIGAND-BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA

Summary for 2PRG

DescriptorPEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, NUCLEAR RECEPTOR COACTIVATOR SRC-1, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... (4 entities in total)
Functional Keywordscomplex (thiazolidinedione-receptor), ligand-binding domain, nuclear receptor, apo, transcription factor, orphan receptor, complex (thiazolidinedione-receptor) complex, complex (thiazolidinedione/receptor)
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains3
Total molecular weight72105.12
Authors
Nolte, R.T.,Wisely, G.B.,Milburn, M.V. (deposition date: 1998-08-14, release date: 1999-07-19, Last modification date: 2011-07-13)
Primary citation
Nolte, R.T.,Wisely, G.B.,Westin, S.,Cobb, J.E.,Lambert, M.H.,Kurokawa, R.,Rosenfeld, M.G.,Willson, T.M.,Glass, C.K.,Milburn, M.V.
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.
Nature, 395:137-143, 1998
PubMed: 9744270 (PDB entries with the same primary citation)
DOI: 10.1038/25931
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
NMR Information
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers202.6%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report