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2PRG

LIGAND-BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
C0003713molecular_functiontranscription coactivator activity
C0005634cellular_componentnucleus
C0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE BRL A 1
ChainResidue
APHE282
AGLY284
ACYS285
AGLN286
ASER289
AHIS323
ATYR327
AILE341
AMET364
AHIS449
ATYR473

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE BRL B 2
ChainResidue
BPHE282
BCYS285
BGLN286
BSER289
BHIS323
BTYR327
BLEU330
BLEU340
BILE341
BMET364
BHIS449
BLEU453
BTYR473

site_idCA1
Number of Residues8
DetailsRESIDUES INVOLVED IN BINDING THE LXXLL COACTIVATOR HELIX.
ChainResidue
AGLU471
ALYS301
ATHR297
AGLN314
AVAL315
ALEU468
ALEU318
ALEU311

site_idCA2
Number of Residues8
DetailsRESIDUES INVOLVED IN BINDING THE COACTIVATOR LXXLL HELIX.
ChainResidue
BGLU471
BLYS301
BTHR297
BGLN314
BVAL315
BLEU468
BLEU318
BLEU311

site_idLB1
Number of Residues11
DetailsTHESE RESIDUES ARE INVOLVED IN LIGAND BINDING.
ChainResidue
AHIS323
AGLY338
AILE341
ALEU469
AHIS449
AGLN286
ATYR327
ALEU330
APHE282
ACYS285
AARG288

site_idLB2
Number of Residues11
DetailsTHESE RESIDUES ARE INVOLVED IN LIGAND BINDING.
ChainResidue
BHIS323
BLEU469
BHIS449
BGLN286
BTYR327
BLEU330
BPHE282
BCYS285
BARG288
BGLY338
BILE341

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues265
DetailsDomain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues16
DetailsMotif: {"description":"9aaTAD","evidences":[{"source":"PubMed","id":"30468856","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9744270","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PRG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36737649","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsMotif: {"description":"LXXLL motif 3"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsMotif: {"description":"LXXLL motif 4"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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