2F4B

Crystal structure of the ligand binding domain of human PPAR-gamma in complex with an agonist

Summary for 2F4B

Entry DOI	10.2210/pdb2f4b/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (5-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPOXY}-1H-INDOL-1-YL)ACETIC ACID (3 entities in total)
Functional Keywords	ppar, transcription activator
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	62515.65
Authors	Lu, I.L.,Peng, Y.H.,Mahindroo, N.,Hsieh, H.P.,Wu, S.Y. (deposition date: 2005-11-23, release date: 2006-02-14, Last modification date: 2024-03-13)
Primary citation	Mahindroo, N.,Wang, C.C.,Liao, C.C.,Huang, C.F.,Lu, I.L.,Lien, T.W.,Peng, Y.H.,Huang, W.J.,Lin, Y.T.,Hsu, M.C.,Lin, C.H.,Tsai, C.H.,Hsu, J.T.,Chen, X.,Lyu, P.C.,Chao, Y.S.,Wu, S.Y.,Hsieh, H.P. Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies J.Med.Chem., 49:1212-1216, 2006 Cited by PubMed: 16451087 DOI: 10.1021/jm0510373 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.07 Å)

Structure validation