2F4B

Crystal structure of the ligand binding domain of human PPAR-gamma in complex with an agonist

Summary for 2F4B

DescriptorPeroxisome proliferator-activated receptor gamma, (5-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPOXY}-1H-INDOL-1-YL)ACETIC ACID (3 entities in total)
Functional Keywordsppar, transcription activator
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight62515.65
Authors
Lu, I.L.,Peng, Y.H.,Mahindroo, N.,Hsieh, H.P.,Wu, S.Y. (deposition date: 2005-11-23, release date: 2006-02-14, Last modification date: 2011-07-13)
Primary citation
Mahindroo, N.,Wang, C.C.,Liao, C.C.,Huang, C.F.,Lu, I.L.,Lien, T.W.,Peng, Y.H.,Huang, W.J.,Lin, Y.T.,Hsu, M.C.,Lin, C.H.,Tsai, C.H.,Hsu, J.T.,Chen, X.,Lyu, P.C.,Chao, Y.S.,Wu, S.Y.,Hsieh, H.P.
Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies
J.Med.Chem., 49:1212-1216, 2006
PubMed: 16451087 (PDB entries with the same primary citation)
DOI: 10.1021/jm0510373
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.07 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers112.0%8.0%12.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report