1K74
The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.
Summary for 1K74
Entry DOI | 10.2210/pdb1k74/pdb |
Related | 1fm6 1fm9 1K7L |
Descriptor | Retinoic acid receptor RXR-alpha, Peroxisome proliferator activated receptor gamma, steroid receptor coactivator, ... (6 entities in total) |
Functional Keywords | the heterodimer of the nuclear receptor ligand binding domains of rxralpha and ppargamma bound respectively with 9-cis retinoic acid and gw409544 and coactivator peptides, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P19793 P37231 |
Total number of polymer chains | 4 |
Total formula weight | 65517.86 |
Authors | Xu, H.E.,Lambert, M.H.,Montana, V.G.,Moore, L.B.,Collins, J.L.,Oplinger, J.A.,Kliewer, S.A.,Gampe Jr., R.T.,McKee, D.D.,Moore, J.T.,Willson, T.M. (deposition date: 2001-10-18, release date: 2001-12-05, Last modification date: 2024-02-07) |
Primary citation | Xu, H.E.,Lambert, M.H.,Montana, V.G.,Plunket, K.D.,Moore, L.B.,Collins, J.L.,Oplinger, J.A.,Kliewer, S.A.,Gampe Jr., R.T.,McKee, D.D.,Moore, J.T.,Willson, T.M. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc.Natl.Acad.Sci.USA, 98:13919-13924, 2001 Cited by PubMed: 11698662DOI: 10.1073/pnas.241410198 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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