1K7L

The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.

Summary for 1K7L

• Entry DOI: 10.2210/pdb1k7l/pdb
• Related: 1fm6 1fm9 1k74
• Descriptor: Peroxisome proliferator activated receptor alpha, steroid receptor coactivator, 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID, ... (5 entities in total)
• Functional Keywords: the 2.5 angstrom resolution crystal structure of the human pparalpha ligand binding domain bound with gw409544 and a coactivator peptide, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q07869
• Total number of polymer chains: 8
• Total formula weight: 142871.19

Authors

Xu, H.E.,Lambert, M.H.,Montana, V.G.,Moore, L.B.,Collins, J.L.,Oplinger, J.A.,Kliewer, S.A.,Gampe Jr., R.T.,McKee, D.D.,Moore, J.T.,Willson, T.M. (deposition date: 2001-10-19, release date: 2001-12-05, Last modification date: 2024-02-07)

• Primary citation: Xu, H.E.,Lambert, M.H.,Montana, V.G.,Plunket, K.D.,Moore, L.B.,Collins, J.L.,Oplinger, J.A.,Kliewer, S.A.,Gampe Jr., R.T.,McKee, D.D.,Moore, J.T.,Willson, T.M.; Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.; Proc.Natl.Acad.Sci.USA, 98:13919-13924, 2001; PubMed: 11698662; DOI: 10.1073/pnas.241410198

Experimental method

X-RAY DIFFRACTION (2.5 Å)