1K7L

The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Peroxisome proliferator activated receptor alpha	polymer	288	32731.0	4	UniProt (Q07869) Pfam (PF00104)	Homo sapiens (human)	PPARalpha
2	B, D, F, H (B, D, F, H)	steroid receptor coactivator	polymer	21	2431.8	4	UniProt (O43792) UniProt (by SIFTS) (Q15788)
3	I, K, M, N (A, C, E, G)	2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID	non-polymer		510.6	4	Chemie (544)
4	J, L (C, E)	YTTRIUM (III) ION	non-polymer		88.9	2	Chemie (YT3)
5	O, P, Q, R, S... (A, C, D, E, F...)	water	water		18.0	242	Chemie (HOH)

Sequence modifications

A, C, E, G: 192 - 468 (UniProt: Q07869)

PDB	External Database	Details
Met 181	-	expression tag
Lys 182	-	expression tag
Lys 183	-	expression tag
Gly 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
His 189	-	expression tag
His 190	-	expression tag
Gly 191	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	140651.1
Non-Polymers*	Number of molecules	6
	Total formula weight	2220.1
All*	Total formula weight	142871.2

*Water molecules are not included.