1K7L

The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0004879	molecular_function	nuclear receptor activity
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
G	0003677	molecular_function	DNA binding
G	0004879	molecular_function	nuclear receptor activity
G	0005634	cellular_component	nucleus
G	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE YT3 C 469

Chain	Residue
A	GLU267
A	GLU451
A	ASP453
C	GLU267
C	GLU451
C	ASP453

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE YT3 E 469

Chain	Residue
G	GLU267
G	GLU451
G	ASP453
E	GLU267
E	GLU451
E	ASP453

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 544 A 469

Chain	Residue
A	PHE273
A	CYS275
A	CYS276
A	SER280
A	TYR314
A	LEU321
A	VAL332
A	PHE351
A	ILE354
A	MET355
A	HIS440
A	TYR464

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 544 C 470

Chain	Residue
C	LEU247
C	GLU269
C	PHE273
C	CYS275
C	CYS276
C	GLN277
C	SER280
C	TYR314
C	MET330
C	VAL332
C	LEU347
C	PHE351
C	ILE354
C	HIS440
C	VAL444
C	TYR464
C	HOH527

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 544 E 501

Chain	Residue
E	GLU269
E	PHE273
E	CYS275
E	CYS276
E	SER280
E	TYR314
E	MET330
E	VAL332
E	PHE351
E	ILE354
E	MET355
E	HIS440
E	LEU460
E	TYR464

---

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 544 G 601

Chain	Residue
G	LEU247
G	ILE272
G	PHE273
G	CYS275
G	CYS276
G	THR279
G	SER280
G	TYR314
G	LEU321
G	MET330
G	VAL332
G	LEU347
G	PHE351
G	ILE354
G	MET355
G	HIS440
G	LEU460
G	TYR464

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	908
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	516
Details	Region: {"description":"Required for heterodimerization with RXRA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19116277","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ET1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Essential for heterodimerization with RXRA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Motif: {"description":"LXXLL motif 4"}

Chain

Residue

Details

---