1K74
The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 238 | 26667.9 | 1 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (human) | RXRalpha |
| 2 | B (D) | Peroxisome proliferator activated receptor gamma | polymer | 283 | 32426.7 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPARgamma |
| 3 | C, D (B, E) | steroid receptor coactivator | polymer | 25 | 2806.2 | 2 | UniProt (O43792) Pfam (PF08832) UniProt (by SIFTS) (Q15788) | ||
| 4 | E (A) | (9cis)-retinoic acid | non-polymer | 300.4 | 1 | Chemie (9CR) | |||
| 5 | F (D) | 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID | non-polymer | 510.6 | 1 | Chemie (544) | |||
| 6 | G, H, I, J (A, D, B, E) | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
D: 206 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Met 195 | - | expression tag |
| Lys 196 | - | expression tag |
| Lys 197 | - | expression tag |
| Gly 198 | - | expression tag |
| His 199 | - | expression tag |
| His 200 | - | expression tag |
| His 201 | - | expression tag |
| His 202 | - | expression tag |
| His 203 | - | expression tag |
| His 204 | - | expression tag |
| Gly 205 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64706.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 811.0 | |
| All* | Total formula weight | 65517.9 |
