1K74
The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Retinoic acid receptor RXR-alpha | polymer | 238 | 26667.9 | 1 | UniProt (P19793) Pfam (PF00104) In PDB | Homo sapiens (human) | RXRalpha |
2 | D | Peroxisome proliferator activated receptor gamma | polymer | 283 | 32426.7 | 1 | UniProt (P37231) Pfam (PF00104) In PDB | Homo sapiens (human) | PPARgamma |
3 | B, E | steroid receptor coactivator | polymer | 25 | 2806.2 | 2 | UniProt (O43792) Pfam (PF08832) UniProt (by SIFTS) (Q15788) In PDB | ||
4 | A | (9cis)-retinoic acid | non-polymer | 300.4 | 1 | Chemie (9CR) | |||
5 | D | 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID | non-polymer | 510.6 | 1 | Chemie (544) | |||
6 | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
D: 206 - 477 (UniProt: P37231)
PDB | External Database | Details |
---|---|---|
Met 195 | - | expression tag |
Lys 196 | - | expression tag |
Lys 197 | - | expression tag |
Gly 198 | - | expression tag |
His 199 | - | expression tag |
His 200 | - | expression tag |
His 201 | - | expression tag |
His 202 | - | expression tag |
His 203 | - | expression tag |
His 204 | - | expression tag |
Gly 205 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 64706.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 811.0 | |
All* | Total formula weight | 65517.9 |