1K74

The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Retinoic acid receptor RXR-alpha	polymer	238	26667.9	1	UniProt (P19793) Pfam (PF00104) In PDB	Homo sapiens (human)	RXRalpha
2	D	Peroxisome proliferator activated receptor gamma	polymer	283	32426.7	1	UniProt (P37231) Pfam (PF00104) In PDB	Homo sapiens (human)	PPARgamma
3	B, E	steroid receptor coactivator	polymer	25	2806.2	2	UniProt (O43792) Pfam (PF08832) UniProt (by SIFTS) (Q15788) In PDB
4	A	(9cis)-retinoic acid	non-polymer		300.4	1	Chemie (9CR)
5	D	2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID	non-polymer		510.6	1	Chemie (544)
6		water	water		18.0	208	Chemie (HOH)

Sequence modifications

D: 206 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 195	-	expression tag
Lys 196	-	expression tag
Lys 197	-	expression tag
Gly 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
Gly 205	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	64706.8
Non-Polymers*	Number of molecules	2
	Total formula weight	811.0
All*	Total formula weight	65517.9

*Water molecules are not included.