1FM9

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.

Summary for 1FM9

• Entry DOI: 10.2210/pdb1fm9/pdb
• Related: 1FM6
• Descriptor: RETINOIC ACID RECEPTOR RXR-ALPHA, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, STEROID RECEPTOR COACTIVATOR, ... (6 entities in total)
• Functional Keywords: the heterodimer of the nuclear receptor ligand binding domains of rxralpha and ppargamma bound respectively with 9-cis retinoic acid and gi262570 and co-activator peptides, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P19793 P37231
• Total number of polymer chains: 4
• Total formula weight: 64221.36

Authors

Gampe Jr., R.T.,Montana, V.G.,Lambert, M.H.,Miller, A.B.,Bledsoe, R.K.,Milburn, M.V.,Kliewer, S.A.,Willson, T.M.,Xu, H.E. (deposition date: 2000-08-16, release date: 2001-02-16, Last modification date: 2024-02-07)

• Primary citation: Gampe Jr., R.T.,Montana, V.G.,Lambert, M.H.,Miller, A.B.,Bledsoe, R.K.,Milburn, M.V.,Kliewer, S.A.,Willson, T.M.,Xu, H.E.; Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.; Mol.Cell, 5:545-555, 2000; PubMed: 10882139; DOI: 10.1016/S1097-2765(00)80448-7

Experimental method

X-RAY DIFFRACTION (2.1 Å)