1NYX

Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist

Summary for 1NYX

Related1KNU
Descriptorperoxisome proliferator activated receptor gamma, (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID (3 entities in total)
Functional Keywordsppar, nuclear receptor, transcription, gene regulation, agonist complex
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63548.69
Authors
Ebdrup, S.,Pettersson, I.,Rasmussen, H.B.,Deussen, H.-J.,Frost Jensen, A.,Mortensen, S.B.,Fleckner, J.,Pridal, L.,Nygaard, L.,Sauerberg, P. (deposition date: 2003-02-14, release date: 2003-07-15, Last modification date: 2011-07-13)
Primary citation
Ebdrup, S.,Pettersson, I.,Rasmussen, H.B.,Deussen, H.-J.,Frost Jensen, A.,Mortensen, S.B.,Fleckner, J.,Pridal, L.,Nygaard, L.,Sauerberg, P.
Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar
J.MED.CHEM., 46:1306-1317, 2003
PubMed: 12672231 (PDB entries with the same primary citation)
DOI: 10.1021/jm021027r
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.65 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers394.1%11.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report