1KNU

LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH A SYNTHETIC AGONIST

Summary for 1KNU

Related1PRG 2PRG
DescriptorPEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, (S)-3-(4-(2-CARBAZOL-9-YL-ETHOXY)-PHENYL)-2-ETHOXY-PROPIONIC ACID (3 entities in total)
Functional Keywordsppar, nuclear receptor, transcription, gene regulation, agonist complex, dna binding protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63046.26
Authors
Svensson, L.A.,Mortensen, S.B.,Fleckner, J.,Woeldike, H.F. (deposition date: 2001-12-19, release date: 2002-12-19, Last modification date: 2017-10-11)
Primary citation
Sauerberg, P.,Pettersson, I.,Jeppesen, L.,Bury, P.S.,Mogensen, J.P.,Wassermann, K.,Brand, C.L.,Sturis, J.,Woldike, H.F.,Fleckner, J.,Andersen, A.-S.T.,Mortensen, S.B.,Svensson, L.A.,Rasmussen, H.B.,Lehmann, S.V.,Polivka, Z.,Sindelar, K.,Panajotova, V.,Ynddal, L.,Wulff, E.M.
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity
J.MED.CHEM., 45:789-804, 2002
PubMed: 11831892 (PDB entries with the same primary citation)
DOI: 10.1021/jm010964g
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.269122.1%4.5%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report