1KNU

LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH A SYNTHETIC AGONIST

Summary for 1KNU
Related1PRG 2PRG
DescriptorPEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, (S)-3-(4-(2-CARBAZOL-9-YL-ETHOXY)-PHENYL)-2-ETHOXY-PROPIONIC ACID (3 entities in total)
Functional Keywordsppar, nuclear receptor, transcription, gene regulation, agonist complex, dna binding protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P37231
Total number of polymer chains2
Total formula weight63046.26
Authors
Svensson, L.A.,Mortensen, S.B.,Fleckner, J.,Woeldike, H.F. (deposition date: 2001-12-19, release date: 2002-12-19, Last modification date: 2017-10-11)
Primary citationAndersen, A.-S.T.,Brand, C.L.,Bury, P.S.,Fleckner, J.,Jeppesen, L.,Lehmann, S.V.,Mogensen, J.P.,Mortensen, S.B.,Panajotova, V.,Pettersson, I.,Polivka, Z.,Rasmussen, H.B.,Sauerberg, P.,Sindelar, K.,Sturis, J.,Svensson, L.A.,Wassermann, K.,Woldike, H.F.,Wulff, E.M.,Ynddal, L.
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity
J.MED.CHEM., 45:789-804, 2002
PubMed: 11831892
DOI: 110.1021/jm010964g
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation
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PDB entries from 2021-06-16