hPPARgamma Ligand binding domain in complex with 9-(S)-HODE

Summary for 2VSR

Related2FVJ 2VV2 1FM9 2VV0 2VV1 2PRG 1KNU 1RDT 3PRG 2VV4 1I7I 1K74 1FM6 1ZGY 1PRG 2F4B 2VST 2G0H 1WM0 4PRG 2VV3 1NYX 2G0G
DescriptorPEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (3 entities in total)
Functional Keywordstranscription regulation, alternative splicing, ligand binding domain, nuclear receptor, diabetes mellitus, zinc-finger, dna-binding, polymorphism, transcription, zinc, obesity, nucleus, receptor, activator, oxidised fatty acid, transcription factor, metal-binding, phosphoprotein, disease mutation
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63788.38
Itoh, T.,Fairall, L.,Schwabe, J.W.R. (deposition date: 2008-04-29, release date: 2008-08-19, Last modification date: 2012-06-06)
Primary citation
Itoh, T.,Fairall, L.,Amin, K.,Inaba, Y.,Szanto, A.,Balint, B.L.,Nagy, L.,Yamamoto, K.,Schwabe, J.W.R.
Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15:924-, 2008
PubMed: 19172745 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.1474
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.266160.4%2.4%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report