2VSR

hPPARgamma Ligand binding domain in complex with 9-(S)-HODE

Summary for 2VSR

Entry DOI	10.2210/pdb2vsr/pdb
Related	1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZGY 2F4B 2FVJ 2G0G 2G0H 2PRG 2VST 2VV0 2VV1 2VV2 2VV3 2VV4 3PRG 4PRG
Descriptor	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (3 entities in total)
Functional Keywords	transcription regulation, alternative splicing, ligand binding domain, nuclear receptor, diabetes mellitus, zinc-finger, dna-binding, polymorphism, transcription, zinc, obesity, nucleus, receptor, activator, oxidised fatty acid, transcription factor, metal-binding, phosphoprotein, disease mutation
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	63788.38
Authors	Itoh, T.,Fairall, L.,Schwabe, J.W.R. (deposition date: 2008-04-29, release date: 2008-08-19, Last modification date: 2023-12-13)
Primary citation	Itoh, T.,Fairall, L.,Amin, K.,Inaba, Y.,Szanto, A.,Balint, B.L.,Nagy, L.,Yamamoto, K.,Schwabe, J.W.R. Structural Basis for the Activation of Pparg by Oxidised Fatty Acids Nat.Struct.Mol.Biol., 15:924-, 2008 Cited by PubMed: 19172745 DOI: 10.1038/NSMB.1474 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation